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  • 2
    Jan
    2013
    4:24am, EST

    Drug-resistant malaria in Thailand threatens deadly global 'nightmare'

    Scientists are battling to stop a drug-resistant malaria that could threaten the lives of millions. "We worry that we are running out of time," one scientist says. NBC News' Ian Williams reports from northwestern Thailand.

    By Ian Williams, NBC News

    MAE SOT, Thailand -- Clipboard in hand, Dr Francois Nosten worked his way down a ward of malaria patients. He stopped in front of five-year-old Ayemyint Than, who sat to attention and smiled. The smile told Nosten as much as his lines of graphs and figures.

    Ian Williams / NBC News

    Ayemyint Than, 5, is being treated for malaria in northwestern Thailand.

    "She's doing well," he said, moving to an older man, whose pale face and dull sunken eyes told a very different story. "Day five, and he's still positive?" he asked another of the doctors. "That's not very good. It means he was very slow to clear the parasite, no?"

    To Nosten, it was further evidence of an alarming rise in resistance to artemisinin, currently the front-line drug in the treatment of malaria. He fears it could be the start of a global "nightmare" in which millions of people could lose their lives.

    "We have to beat this resistance, win this race and eliminate the parasite before it’s too late. That's our challenge now," he said.

    He said that artemisinin should take about 24 hours to deal with the parasite, but it was now taking three or four days in some cases. "We are going to see patients that don't respond to the treatment anymore,” he warned.

    Nosten runs the Shoklo Malaria Research Unit, which is part of the Faculty of Tropical Medicine at Thailand's Mahidol University.

    The unit has a string of clinics on both sides of the Moi River, which marks the porous border between Thailand and Myanmar.

    Ian Williams / NBC News

    Migrants cross the Moi River, marking the border between Myanmar and Thailand.

    Nosten set up the first one in 1986, since when there has been a steady fall in the total number of cases of malaria, but most recently a worrying emergence of drug resistance.

    He first sounded the alarm in research published earlier this year, following the emergence of similar drug resistance along the Thai-Cambodia border.

    Full health coverage from NBC News

    Nosten’s not sure whether the resistance he's found has spread from the Cambodia border or is home-grown. Either way, he's worried.

    "It means that all the progress of the last 10 to 15 years will be lost," he warned. "Now the resistance is here, we worry that we are running out of time."

    Ian Williams / NBC News

    Staff examine a baby who has been brought to the clinic with a fever, suspected to be malaria.

    The malaria parasite -- carried by infected mosquitoes from person to person -- still kills an estimated 655,000 people a year.

    That's almost 2,000 a day, mostly in Africa, with children being most at risk.

    If the world loses its front-line drug, the impact could be devastating.

    "The nightmare scenario is that the resistance will travel," Nosten said.

    "We know what will happen in Africa when resistance is bad because we've been there before in the 1990s with chloroquine (another anti-malarial drug) … millions of deaths," he warned.

    "We must prevent artemisinin resistance reaching Africa, but we also need to control it for the people in Asia - for their future."

    Ian Williams / NBC News

    Dr Francois Nosten, right, consults staff as he meets malaria patients at a clinic near Mae Sot, Thailand.

    Resistance to just about every major anti-malarial drug has started in the border regions that have been home to Nosten for more than 25 years.

    Nobody knows exactly why, but poverty, conflict and large migrant and refugee populations constantly on the move all likely play a part. As do fake drugs or a failure to properly complete a course of treatment.

    In the case of chloroquine, once the anti-malarial drug of choice, it took less than 20 years for resistance to spread from the borders of Thailand to Africa.

    Study: Mosquitoes change habits to avoid anti-malaria nets

    Nosten is worried that artemisinin resistance is growing much faster than he'd anticipated, with the drug failing initially to fully clear the parasite in more than half the cases he now sees.

    "It initially goes after a few days, then it comes back. We see that more and more now," he said.

    "In 2009, we still had 90 percent of patients cured. In 2010, it dropped to 60 to 70 percent. Now it's about 50 percent," he added.

    Ian Williams / NBC News

    Migrants from Myanmar wait to be examined at a clinic on the Thai side of the border.

    Some scientists claim this is too alarmist, since the parasite does eventually die, with longer treatment and higher drug doses, but Nosten sees no room for complacency.

    "We have to respond quickly, not next year or three years' time. It's now or probably it will be too late," he said.

    Artemisinin comes from a Chinese plant and is quick, potent and with no side effects. Little wonder it has been hailed as a wonder drug, the golden bullet in the global fight against malaria.

    What makes the resistance so worrying is that there is no new drug ready to replace it.

    Nosten said that although several drugs are in development, they could be five to 10 years away from deployment "if they make it  … and we haven't got five to 10 years.”

    The Shoklo Malaria Research Unit runs its own labs fashioned out of a sprawling old Thai house in the border town of Mae Sot, where teams of research scientists are working to better understand the parasite and the mosquitoes that carry it from person to person.

    It is here that Chiara Andolina keeps mosquitoes that are literally hand-reared -- fed from her arm, which she extends through a mesh hole into a container of the hungry creatures every three days.

    "Usually I feed around 600 of them in a cage like this," she said.

    Of course these are not infected mosquitoes, though watching them settle on her arm for a good lunch is not a sight for the squeamish.

    Read more international coverage from NBC News

    In another room, Nosten settled over photographs showing the rapid development of the parasite once it has invaded a blood cell.

    "If you can kill them very, very young -- like these -- they don't have time to develop into big fatty ones," he said, his pen jabbing at the photo. "These fatty ones are the ones that get stuck in your brain and kill you."

    In other rooms, the DNA of parasites was being isolated and sequenced and drugs were being tested as part of Nosten and his team’s efforts to figure out what's behind the emerging resistance.

    They are also looking for vulnerabilities and new ways to attack their enemy.

    "It's hugely important to understand what's going on and contain it if we can," Nosten said. "We need to try things. We need to explore. It’s like exploring new territories in malaria."

    Bazell: Malaria vaccine a half-effective, temporary protection

    The French scientist has spent most of his working life in the tropics, initially with the medical humanitarian group Médecins Sans Frontières.

    He believes he is engaged in a vital battle -- "a race against malaria" -- as he puts it.

    After so many years on the malarial front lines, the battle has become deeply personal.

    He dreams of completely eliminating this familiar but wily enemy.

    However, he also knows that with the emergence of artemisinin resistance the stakes have never been higher.

    More world stories from NBC News:

    • Drug-resistant malaria threatens deadly global 'nightmare'
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    Follow World News from NBCNews.com on Twitter and Facebook

     

     

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  • 19
    Apr
    2012
    10:14am, EDT

    Soccer or sex? Thai teens ponder puzzling choice

    Ploy Bunluesilp / NBC News

    Panida Saengjan became pregnant at 16 years old, when she was just in high school in Bangkok. She is seen her with her now 4-year-old son Haroon who her mother is raising.

    By Ploy Bunluesilp , NBC News

     
    BANGKOK, Thailand – If you are a teen with a sexual urge, what should you do?

    It's a question faced by young people across the world, and one met with many responses.

    So high school seniors in Thailand were perplexed this year when they were asked for the answer in a nationwide multiple-choice test for students hoping to win a coveted place at university. They were given five possible options to choose from:

    A: Call friends to go play football (soccer)

    B: Talk to your family

    C: Try to sleep

    D: Go out with a friend of the opposite sex

    E: Invite a close friend to see a movie

    Most students had no idea how to respond. And it quickly became clear that they were not the only ones who struggled to identify the right answer. Parents and teachers were equally baffled.



    The story soon attracted national media attention, and Thai educational experts were interviewed to share their insights. But even they seemed uncertain. The tentative consensus was that students were probably expected to pick option B — “Talk to your family.”

    It seemed like the answer adults might want to hear, even though most teenagers in the real world would be appalled at the very idea of discussing their sexual urges with their parents. The most realistic answer was probably option D — go on a date.

    So there was widespread incredulity when the preferred answer was eventually revealed by Dr. Samphan Phanphrut, head of the national exam board that drew up the tests. It was option A —“Call friends to go play football.” Regardless of whether they were male or female, Thai youth were supposed to deal with sexual urges by playing soccer.

    For many Thais, the key lesson learned from the saga had nothing to do with soccer. Rather, it was that Thai officials have a total lack of understanding about the lives of teenagers and the importance of sensible sex education.

    Growing teen pregnancy problem
    It's an issue that is causing increasing problems in this Southeast Asian country.

    Ploy Bunluesilp / NBC News

    Haroon, a 4-year-old in Bangkok being raised by his grandmother because his mother was just 16 years old when she became pregnant.

    "The number of pregnant teenagers is growing every year. And they are getting younger and younger," said Apiradee Chappanapong of Plan Thailand, an NGO that champions children's rights and education.

    In fact, Thailand has the second-highest pregnancy rate among 15-19 year-olds in the world, according to the government’s Office of Welfare Promotion, Protection and Empowerment of Vulnerable Groups. (South Africa has the highest rate).

    The issues in Thailand are complex. Contrary to the country's image as a hedonistic sex tourism destination, Thai culture remains highly conservative, but premarital sex is widespread although many older Thais regard it as taboo. (As a result, underage girls are often pressured to marry, especially in rural areas.)

    This conservatism means subject is rarely discussed in Thai families, and as the debacle over this year's university exams demonstrated, schools are also failing to teach Thai youth what they need to know.

    Many teachers and education ministry bureaucrats refuse to acknowledge that premarital sex is a reality. Instead of teaching teenagers how to avoid pregnancy through the use of contraception, they preach abstinence. And when Thai teenagers become pregnant, they often have nobody to turn to. Legal abortion is only available to teenagers if their parents approve, and many Thai girls don't consider that an option.

    “I don’t think my school taught me enough about sex education,” said Nat who asked not to reveal her full name, a 17-year-old who became pregnant after running away from her home in an area of northern Thailand where traditional values remain strong.

    Unable to get a legal abortion because she was estranged from her parents, she chose the dangerous option of ordering abortion pills online and taking them without any medical supervision. She told me she suffered severe vaginal bleeding afterwards.

    Many conservative Thais deny that outdated and incompetent education is the problem. They say Thai teenagers are being corrupted by dangerous modern influences such as racy movies, social media and Internet chat rooms. Facebook was even cited as one of the causes of Thailand's growing teenage pregnancy crisis in a recent study by the National Economic and Social Development Board (NESDB). 

    Dangerous illegal abortions
    Another controversial issue is whether Thailand's abortion laws should be reformed. Approximately 95 percent of Thais are Buddhists, according to the CIA World Factbook, who believe taking any life is a sin. Officially, abortion is illegal except in cases of rape, incest or underage sex, or when the mother's physical or mental health is at risk.

    Even when women have a legitimate reason to undergo a legal abortion in Thai hospitals, many are deterred by the judgmental attitude of doctors and nurses, according to 39-year-old activist Supatra Panuthut, who counsels women with unplanned pregnancies at Sahathai Foundation in Bangkok.

    For most women who want to terminate a pregnancy, the only option is to do so illegally. In many cases, abortions are conducted using unsafe procedures and in unsanitary conditions. In a notorious case in 2010, more than 2,000 aborted fetuses were discovered at a temple in Bangkok after locals complained of an unpleasant smell. Earlier this April, a five-month-old fetus was found dumped in a hospital bathroom. Newborn babies have also been found abandoned in bus shelters and garbage bins.

    A small number of abortion clinics run by NGOs providing safe and compassionate treatment occupy a legal grey area: they are technically illegal, but the authorities have generally allowed them to operate, as long as they do not promote their services too openly.

    But recently police raided one of these clinics after a well-known model told the media she had an abortion there. Panuthut fears the raid will end up discouraging some women from seeking abortions at responsible clinics and could lead to more unsafe backstreet abortions.

    It seems unlikely that the law will be changed to allow more Thai women to legally terminate their pregnancies. Successive Thai governments have shown no enthusiasm for such a controversial move, and indeed some Thais want to see the law tightened even further so that abortion is totally outlawed.

    Coping with unwanted pregnancies
    Meanwhile, out of the approximately 250,000 Thai teenagers who become pregnant each year, half of them seek abortions, according to Dr. Yongyut Wongpiromsarn, Senior Expert in Mental Health, Thai Ministry of Public Health.

    That means more than 100,000 children are being born each year to teenage mothers who in many cases cannot properly look after them.

    Often these children are raised by their grandparents or other relatives, rather than their biological mothers.

    This was how Panida Saengjan coped when she became pregnant at the age of 16 while she was a high school student in Bangkok. She told me she was terrified of the dangers of an illegal abortion, but admitted she was also too immature to look after her baby, a boy she named Haroon.

    Now 4 years old, Haroon has been raised by Saengjan's mother. When I met them at their home, Saengjan was laughing and playing with Haroon, whom she said was more like a little brother to her than a son.

    Many teenage mothers end up giving their children to foster homes. Palm, an 18-year-old I interviewed who spoke on the condition of anonymity, wept as she told me about how she had to give away her 5-month-old son after her boyfriend broke up with her.

    Government officials insist they are taking the problem of teen pregnancy seriously. But while Thai bureaucrats remain so detached from reality that they consider it appropriate to tell teenagers to choose soccer instead of sex, there seems little prospect of a sensible solution any time soon. 
     

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