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    7
    Jun
    2012
    7:11am, EDT

    For parents: Opiate use warning signs and getting help

    Young recovering heroin addicts Tej Yaich, 20, Holly Yates, 20 and Tara McCormac, 22, and Dr. Joseph Gay share their stories and discuss the growing heroin crisis in Ohio.

    By Rita Rubin

    The crackdown on illegal use of prescription painkillers in some parts of the country has fueled increased use of heroin -- a cheaper and more dangerous alternative -- among teens. Both the painkillers and heroin are opiates, a class of drugs derived from the poppy plant.

    If parents suspect their teens are using opiates, quick action is urged.  Warning signs include:

    • Missing pills from prescription bottles in the home. Adults who’ve been prescribed opiate painkillers should be vigilant about storing them out of reach of teens. Young people often think the drugs are safe because a doctor prescribed them.
    • Behavioral changes, such as diminished interest in school, extracurricular activities and friends.
    • Indifference or even sleepiness, because opiates are sedatives.
    •  Constant requests for money with nothing to show for it. Opiate users eventually build up tolerance to the drugs, so they need increasing amounts to achieve the same effects.
    • Needle marks or unseasonable long-sleeved shirts to cover them up. Injecting heroin carries the added risk of disease transmission by shared needles. Heroin’s purity is increasing, though, so teens can get the same high from snorting it as from injecting it.

    “Parents should not hesitate to force their kid to seek help for this,” says Dr. Joe Gay, an Athens, Ohio, psychologist who treats addiction, noting the “ever-present danger” of overdose. “This is such a critical condition, and it’s progressive. It’s important to get help as soon as you can.”

    And studies show that the earlier it’s treated, the greater the likelihood of long-term abstinence, says Dr. Lynn Fiellin, a Yale internist who treats and studies addiction.

    Sarah Mayer, 27, and her father Randy, 54, of Hilliard Ohio, share her story of addiction and recovery with NBC News.

    What to do
    Treating teens is particularly challenging, she says, because their parents are usually the ones seeking help, not the teens themselves.

    There are two medications used to treat addiction to opiates and opioids, which are synthetic opiates: methadone and buprenorphine, sold under the brand name Suboxone. Methadone is available only at methadone clinics, so patients must go to a clinic every day to drink the drug. But patients can get a prescription for buprenorphine --  launched in 2003 in the United States -- at their local pharmacy and take the pills in the privacy of their own home.

    “Methadone is still considered the treatment of choice for maintenance in adolescents,” Fiellin says. “Increasingly, there’s more use of buprenorphine in teenagers, but it’s still limited.”

    The safety and effectiveness of Suboxone in children under age 16 has not been established, according to Food and Drug Administration-approved prescribing information. In 2009, fewer than 1 percent of doctors who prescribed buprenorphine were pediatricians, according to government data. However, a growing body of research supports the use of buprenorphine in teens, Fiellin says.

    SAMHSA, the federal Substance Abuse & Mental Health Services Administration, has a searchable substance abuse treatment locator at findtreatment.samhsa.gov. SAMHSA also maintains a searchable locator of physicians and treatment programs that use buprenorphine.

    Related stories:

    • Mom's last resort: Opiate antidote saves lives
    • How prescription painkillers pave the way to heroin

     

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    Explore related topics: oxycontin, heroin, featured, vicodin, opiates
  • 7
    Jun
    2012
    7:11am, EDT

    Opiate addiction: How prescription painkillers pave the way to heroin

    Sarah Mayer, 27, and her father Randy, 54, of Hilliard Ohio, share her story of addiction and recovery with NBC News.

    By Stacey Naggiar, NBC News

    The use of prescription painkillers recreationally is at epidemic levels, according to the Centers for Disease Control and Prevention. What is it about the pills that makes them so dangerously addictive and a potential gateway for heroin?

    The surprising answer, at least to many non-medical professionals, is that the common painkillers that doctors and dentists prescribe to patients after injuries and surgeries have the same active ingredient as the drug that alleyway users inject into their arms. And both act in similar ways on the human brain to produce a sense of pleasure that can overwhelm its reasoning functions.

    While many who abuse prescription painkillers think of heroin as a low-class drug that will never make its way into their lives, they don’t realize, they’re already addicted to a form of it.

    Prescription painkillers of the sort that 12 million Americans used nonmedically in 2010, according to the CDC, are narcotic opioid drugs, more commonly referred to as opiates. They include hydrocodone and oxycodone, also known by the brand names Vicodin and Oxycontin, respectively. 

    Reward system
    According to the National Institute on Drug Abuse, when opiates are consumed, they enter the bloodstream and activate neurotransmitter receptors in the brain’s reward system. Scientists call the link between the drug and the receptor a lock and key relationship, because one specific neurotransmitter activates specific receptor molecules, the same way only one key fits a particular lock.

    When the opiates reach the opiate receptors, the latter release the hormone dopamine.  The dopamine – which acts as an “excitatory neurotransmitter” – produces feelings of pleasure and satisfaction.  It’s this action at the most basic cellular level that provides the foundation for drug addiction. 

    Young recovering heroin addicts Tej Yaich, 20, Holly Yates, 20 and Tara McCormac, 22, and Dr. Joseph Gay share their stories and discuss the growing heroin crisis in Ohio.

    Although the initial effect of the drug is rewarding and results in a “high,” or feeling of euphoria, the effect is time stamped. When it wears off, the user feels much worse than before having taken the drug. 

    Addiction psychiatrist Dr. Stuart Gitlow, president of the American Society of Addiction Medicine, compares this phenomenon to alcohol use, saying that people drink for the immediate effect, regardless of the inevitable hangover that will follow.

    "The only connection a patient makes is that use of the drug leads to immediate relief -- not the longer-lasting discomfort that follows. Unfortunately, the drug causes both the immediate relief and the following discomfort. As time passes, the discomfort becomes more apparent than the relief and the drug is used merely in an effort to avoid the discomfort that the drug has caused in the first place."

    Gitlow explains that humans are not biologically programmed to think about cause and effect in this way. “The only thing a patient connects in their head is with the immediate relief -- not the effect felt days later,” he said. 

    Also, as with alcohol, the pleasurable effect diminishes over time, he said.

    At the cellular level, chronic activation of the opiate receptors eventually saturates them -- requiring higher and higher dosages of the drugs to achieve the same pleasant feeling. It is for this reason that an addict will seek more potent forms of the opioids.  

    “There are certain medications that invite an escalation to more serious drugs and narcotics and opiates are two of those” said Dr. Nancy Snyderman, NBC News chief medical editor.

    The speed with which the different forms of opiates enter the bloodstream and flood receptors depends on the form in which it’s consumed, explains Snyderman. Consuming a pill by mouth can take up to a few hours to have an effect because it has to be digested by the stomach and intestines before it makes its way into the bloodstream. Injection is the second-fastest way to achieve the desired effect, as the drug enters the bloodstream instantly but has to make its way to the brain. Snorting a crushed pill or a powder crosses the blood-brain barrier in a matter of seconds; that’s what makes snorting so addicting and the drug delivery system of choice. 

    It also means there’s less margin for error if a person has a drug reaction or overdoses, Snyderman said.

    In an opiate overdose a person may experience confusion and physical discomfort. In severe cases, a person’s breathing can slow down so much that breathing stops, resulting in a fatal overdose. The CDC estimates that more than 100 people die every day from unintentional drug overdoses -- many of them involving prescription pain killers. 

    In addition to the immediate effects produced by the drugs, numerous short- and long-term side effects can be associated with opiate use and abuse.

    Among the most common side effects reported are constipation, nausea and what’s known as pin-point pupils. As an addict increases consumption, the side effects become more severe and can include extreme sleepiness and slowed respiration and pulse rates.

    The most widely known side effect is the physical dependence that occurs with long-term use.

    Dr. Joe Gay, director of Health Recovery Services in Ohio, points out that “As tolerance goes up, susceptibility to withdrawal becomes a real factor.” Withdrawal symptoms can be excruciating and including muscle aches, anxiety, sweating and insomnia, to name a few. 

    Like any addiction, opiate abuse is considered a relapsing brain disease.  While you can’t predict whether a given person will become addicted to drugs or not, certain factors can increase a person’s risk, including genetic makeup, environment, socioeconomic status, and others, researchers say. 

    One example comes out of a new study from the Seattle Children’s Research Institute, in the June issue of the Journal of Adolescent Health.  It found that adolescents and young adults with mental health disorders were about 2 ½ times more likely to become long-term opioid (synthetic opiate) users that their peers without such disorders.

    Msnbc.com contributor Rita Rubin also contributed to this report.

    Read more of NBC's special report:

    Crackdown on painkiller abuse fuels new wave of heroin addiction
    For parents: Opiate use warning signs and getting help

    167 comments

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    Explore related topics: heroin, featured, opiates
  • 7
    Jun
    2012
    6:08am, EDT

    Crackdown on painkiller abuse fuels new wave of heroin addiction

    Sarah Mayer, 27, and her father Randy, 54, of Hilliard Ohio, share her story of addiction and recovery with NBC News.

    By Lisa Riordan Seville and Hannah Rappleye, NBC News

    LANCASTER, Ohio -- Holly Yates started using painkillers in the ninth grade, at parties and hanging out with friends. The pills were everywhere, easy to get and cheap. By the time she was 18, she was abusing oxycodone, Percocet and other pills every day. 


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    Then they stopped being enough. 

    “My cousin, she was into heroin and I started hanging out with her,” said Yates, a hazel-eyed 20-year-old. “She told me about it, and I was like, ‘I want to try it.’ The first time that I shot it up, it was like, ‘Where has this been all my life?’”


    Experts say Yates and others in this town of about 38,000 southeast of Columbus are on the leading edge of a frightening new drug abuse trend – one that is ironically being fueled by a national crackdown on prescription painkillers. While new regulations and law enforcement efforts have significantly reduced the supply of these drugs, they say, those efforts have inadvertently driven many users to another type of opiate that is cheap, powerful and perhaps even more destructive – heroin.

    “It’s an epidemic,” said Dr. Joe Gay, director of the regional addiction and mental health clinic Health Recovery Services, who has studied patterns of drug use in the state.

    A flood of cheap heroin from Mexico, which is now one of the leading sources of the drug to the United States, is one reason for the return of the scourge. According to the Justice Department, the drug is showing up in new areas, including upscale suburban towns where heroin was once rare. 

    In Illinois, for example, researchers at Roosevelt University have found a spike in young suburban heroin abusers. Long Island, New York, has in recent years seen a rash of addiction among the young. A spike in heroin use and related crime has Dane County, Wis., reeling. Even states like Washington, where heroin has a longtime presence, have seen a sharp increase among young users. In King County, home to Seattle, nearly a third of those entering treatment for heroin abuse in 2009 were between ages 18 and 29 -- a sharp increase from a decade before.

    With increased availability has come a spike in the number of visits to emergency room visits for issues related to heroin use, including a 13 percent increase from 2005 through 2009, according to the national Drug Abuse Warning Network. The highest rates of admission were for young adults, 21 to 24 years old.

    “Twenty years ago, half of the heroin addicts in treatment lived in two states — New York and California,” said Gay. "(Now, in Ohio) we’re seeing it spread out of the cities, into the suburbs and into the rural areas.”

    The demographics of heroin addiction are also shifting, he said. 

    'It's not going away'
    Until a few years ago, addicts were overwhelmingly men who lived in urban areas, many of them from racial minorities. An alarming number of those entering treatment programs in Ohio -- a good measure of addiction -- are young, he said. Most are white. They are from poor rural counties and wealthy suburbs. Many are girls and women.

    In Ohio, the new face of heroin addiction could be the girl or boy next door.

    “Everybody does it,” Yates said. “It’s just here, and it’s not going away.” 

    ***

    Sarah Mayer, 27, was an early traveler on the path from dabbling in prescription pills to putting a needle in her arm.

    Born and raised in Hilliard, a tree-lined suburb of Columbus, she grew up in what is, by all accounts, a loving home. Her father works at the local bank. Her mother is a nurse.

    Derailed plans
    In high school, Mayer went to parties and drank occasionally, but she kept her grades up. During her last year in high school, in 2002, she took college classes. After graduation, she started a fully-paid-for nursing program. But her plans were derailed by addiction to oxycodone, an opiate-based painkiller found in many medicine cabinets across the country.

    “I really didn’t know what I was getting myself into,” Mayer said. By 2005, she and her boyfriend were taking the pills regularly to get high. But over time, the effects diminished.

    One day in early 2006, Sarah and her boyfriend found themselves nearly broke and without the pills they needed. Desperate and sick with withdrawals from the opiates, her boyfriend left the house to try to find pills.

    He came back with a bag of powder heroin.

    “He knew how I felt about heroin,” Mayer said. “That was the one thing I said I would never do.”

    Young recovering heroin addicts Tej Yaich, 20, Holly Yates, 20 and Tara McCormac, 22, and Dr. Joseph Gay share their stories and discuss the growing heroin crisis in Ohio.

    Despite her conviction, within 24 hours, she had snorted it. She would spend another three years chasing that first high. “It was almost like all of the wind was knocked out of my chest, I could barely hold my head anymore,” said Mayer. “It was like my whole body just exhaled.” 

    Soon, she began injecting it. It would take her years, and at least six trips to recovery programs, before she successfully got clean in October 2009. She’s now working toward a degree in nursing, and recently made the dean’s list. 

    Related stories

    • Mom's last resort: Opiate antidote saves addicts' lives
    • Opiate addiction: How prescription painkillers pave the way to heroin
    • For parents: Opiate use warning signs and getting help 
    • Cheap, ultra pure heroin kills instantly

    The addiction was something the Mayer family never saw coming. 

    “There was never a thought that ever entered my mind that I would ever lose a child through addiction,” said Randy Mayer, Sarah’s father. “Watching this thing grab her and not let go, I mean, it was a horrible time.” 

    But in Hilliard, where he also grew up, Randy Mayer said he is seeing this happen to others. 

    “I’ve met some other families, locally here -- they’re dealing with the same kind of situation,” he said. “The fact of the matter is, these towns like this are fertile for this to spread.” 

    ***

    Paul Coleman, director at the Maryhaven clinic near Columbus, where Mayer sought treatment, said about a quarter of the nearly 130 adolescents currently getting treatment there have used opiates --  something he’s never seen in his 22 years at the center.

    “A few years ago if you would have asked me how many young patients I would have using opiates I wouldn't have said 25 percent,” Coleman said. “I would have said none.”

    The White House has called prescription drug abuse the nation’s fastest-growing drug problem. The Centers for Disease Control and Prevention has officially dubbed it an epidemic.

    'Crisis'
    In Ohio and elsewhere, however, the beast has two heads. Opiate abuse, which includes both prescription painkillers and heroin, has become a “crisis of unparalleled proportions,” according to Ohio’s Department of Alcohol and Drug Addiction Services. In 2001, just eight of Ohio’s 88 counties reported a significant number of patients were entering substance abuse treatment for opiate addiction. By the same measure, 85 of Ohio’s 88 counties reported an opiate problem in 2010.

    The state has taken action. In 2006, it implemented a system to track prescriptions to help prevent so called “doctor shopping,” where addicts move from one physician to the next looking for prescriptions. Last year, it also passed a law to help fight “pill mills,” unscrupulous storefront clinics known for readily dispensing prescriptions.

    Similar measures have been taken across the nation. Combined with new pill formulations that make the medication harder to crush up to snort or shoot, the efforts have curbed supply and abuse. Experts agree this is a positive step. But in Ohio, the crackdown has had unexpected consequences.

    The pills have become expensive, and often hard to obtain. Prescription opiates now sell for anywhere from $30 to $80 dollars a pill. A $10 bag of heroin offers a similar or better high.  Unable to find pills, or afford them, addicts go looking for something else to feed the craving. Heroin is cheap, plentiful and potent.

    It is also deadly. In fact, the state saw a record number of heroin-related deaths in 2010, which now account for one in every five overdose deaths in the state. Cuyahoga County, home to Cleveland, recorded 106 heroin-related deaths in 2011 -- an increase of nearly 180 percent since 2003, according to the Cuyahoga County Medical Examiner's Office. In early May, Loraine County, Ohio, saw five fatal overdoses in 10 days due to a batch of highly potent, or badly cut, heroin. Experts worry other counties may soon follow suit, and that those dying might be among what the Ohio Department of Alcohol & Drug Addiction Services reports show is the fastest growing demographic of heroin users -- young people between ages 20 and 35. 

    ***

    It’s an addiction that surprises even those who find themselves in its grip.

    “If you were to tell me that I was going to use heroin ... the same week in which I used it, I probably would have laughed in your face,” said Tej Yaich, a 20-year-old from Pickerington, Ohio. “That’s something that I would never have done.”

    For Yaich, who has been sober for more than a year, addiction started at home. His parents had prescriptions sitting unused in the medicine cabinet. Yaich said he was 15 when he first tried them, crushing them up at night so his parents wouldn’t hear the noise. The experiment became a habit. Then the supply started to dry up.

    “One day I went to call my guy that was selling to me and he said he didn’t have pills at that time, but he had something equally as good,” said Yaich. “He said, ‘You’ll like it.’”

     What the dealer had was heroin, and he was right. Yaich started by snorting it, then quickly moved on to shooting up. From one bag, he worked himself up to two, then five. At the height of his addiction, he said, he injected up to 25 bags a day. 

    ***

    Yaich’s story is typical of those that Dr. Steven Matson hears from young people coming into his clinic at Nationwide Children’s Hospital in Columbus. Matson, who helped Yaich recover, runs a program there that uses a fairly new medication called buprenorphine, a semi-synthetic opioid that when used correctly helps to curb cravings to assist in recovery.

    When Matson started this work three years ago, the young people coming into his clinic were “fringe,” he said. Now they are as often from upscale suburbs of Columbus as from poorer, more rural areas.

    “Because of the availability of these drugs now, it is not an usual story that we hear, ‘I went to a party, some friends there were doing heroin, so I shot up,’” he said. “It seems like madness that you would go to a party and never have used anything and then use heroin. But that’s what’s happening with some children.”

    Matson’s program also helped Holly Yates recover. She’s been sober since Thanksgiving Day 2010. For more than a year, she’s held a job as a stylist at a local hair salon. She saved up to buy herself a silver Honda Accord. In the back seat are two car seats for her young nephews, who her older brothers now trust her to babysit.

    But things can be lonely in Lancaster, where she says nearly everyone her age uses drugs, and many are hooked on heroin.

    “It’s just hard being young and staying clean,” Yates said. “I mean this town, it’s just, like, that’s all that’s here.”

    “I just want kids my age to know that you don’t have to keep using,” she added. “You can be clean, and you can have a better life.”

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Rita Rubin is a contributing health and parenting writer for msnbc.com and TODAY.com. Previously, she covered health and medicine for USA Today and U.S. News and World Report. She is also the author of What If I Have a C-Section?

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