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    26
    Apr
    2013
    3:40am, EDT

    Moldy marijuana? Legal markets spark push for health, safety standards

    Elaine Thompson / AP

    Officials in Washington and Colorado are struggling to come up with new health and safety rules to cover new markets after those states legalized recreational marijuana use.

    By JoNel Aleccia, Senior Writer, NBC News

    Marijuana may soon become mainstream for adults in Colorado and Washington state, but before it reaches that point, regulators face a tall task: making sure that newly available pot products don’t become a hazard to public health.

    Months before legal sales of the drug begin, officials in both states are struggling to come up with health and safety rules to govern a menu of marijuana offerings ranging from leafy greens to food and drinks.

    Pot, like other agricultural commodities, could be subject to problems ranging from mold, mites and pesticide residue in the raw plants to solvents, E. coli, salmonella and run-of-the mill food safety risks in prepared products, experts say.

    Government agencies such as the Food and Drug Administration won’t weigh in because marijuana remains illegal under federal law. That leaves state officials to come up with a framework for policing production and distribution for an entirely new industry.

    “It’s important for us to do it because it’s public safety and there’s no U.S. FDA oversight here,” said Randy Simmons, the Washington State Liquor Control Board project manager in charge of implementing Initiative 502. “Things that would be FDA rules don’t exist.”

    Voters in both states legalized recreational marijuana use for adults last fall. Washington is set to issue producer, processor and retail licenses by Dec. 1; Colorado is set to start sales by January. 

    As it stands now, laws in both states skirt the public health issues of medical pot production. No quality control tests are required; there’s no mechanism for recalling contaminated pot products. And the framework for new rules remains a work in progress.

    “Currently, there’s really nothing codified,” said Julie Postlethwait, spokeswoman for the Colorado Department of Revenue, which will run a new adult marijuana program. Under that state’s existing law, medical marijuana products were explicitly excluded from state rules governing food and drugs.

    In Washington state, a burgeoning market for “medibles” -- foods infused with medical marijuana -- has flown almost entirely under any regulatory radar.

    Producers like Karen Brower, co-owner of Puff n Stuf products, say they’ve taken it upon themselves to make sure that food safety is a top priority.

    “I’m concerned about it, of course, because that’s huge for us,” says the 54-year-old Tacoma woman. “If the health department came into my kitchen, I’m sure that I would pass.”

    Marijuana susceptible to mold, pests
    Still, there are no tests for Brower or her partner, Julie Guterson, 54, to take, no inspectors to review her stainless steel sinks or to review the sanitizing cycle of her dishwasher. She sees the need for new regulations for the larger recreational pot market, but she’s worried it might create stricter standards that her small operation will be unable to meet.

    “We just put our nose to the grindstone and we just keep pumping out medibles for patients,” she said. “That’s what we’re going to do right now.”

    John Brecher / NBC News

    Julie Guterson sells cannabis-infused foods at the Puff n Stuf booth in one of the two locations of the NW Cannabis Market in Seattle. "I'm working out of my home. We have no pets - we tie our hair back and wear clean shirts."

    Some larger producers, however, didn’t wait for government officials to impose health and safety standards. Tripp Keber, chief executive of Dixie Elixirs & Edibles in Denver, says his multiple product lines of pot-infused mints, candies, snacks and sodas already adhere to federal standards for quality.

    “Anyone can make a pot brownie, but fewer can make a dozen,” he said. “Even fewer can make 5,000 with the same consistency.”

    Keber claims to be the largest tester of medical cannabis in Colorado, sending samples of raw material and finished products to CannLabs Inc., a medical marijuana testing laboratory.

    Genifer Murray, the lab’s chief executive, says she conducts tests now for potency and for the presence of solvents, but adds that there’s so much more that could be detected.

    “We will offer pesticide and microbial testing,” she said. “A lab previous to mine has found E. coli and salmonella in the flowers.”

    Marijuana is susceptible to pests and to mold, which can pose a health hazard. There have been at least two cases of fungal lung diseases linked to consuming moldy marijuana, according to a 2011 report in the Mediterranean Journal of Hematology and Infectious Diseases.

    'Someone's going to cut a corner'
    Simmons, the Washington state project leader, says that officials there have done the research they need to create a new system for regulation, one that likely will be modeled on existing state Department of Agriculture food safety regulations. Draft rules are scheduled to be issued in mid-May and refined after public comment.

    The new standards will have to provide methods not only to detect impurities, but also to confirm the strength of the active ingredients. Plus, they will need to provide rules for reflecting those findings on the labels, experts say.

    With testing and quality control in place, the available marijuana may become even more attractive to consumers seeking the assurance of regulation, said Mark Kleiman, a professor of public policy at the University of California, Los Angeles, who is advising Washington about its new law.

    “The commercial system will be able to compete with the medical market and the illicit market if it offers not only legality, but a product of known content and an absence of harmful contaminants,” he said.

    The prospect of an expanded adult marijuana market also leaves advocates eager for mandatory testing – and new certification for the labs that do it.

    “There’s never been a death from cannabis use,” says Murray, “but my worst fear is a death down the road from cannabis contamination.”

    That view is shared by Randy Oliver, chief scientist at Analytical 360, a Seattle laboratory that tests marijuana. He’s seen his share of insects, mites and powdery mold on improperly tended marijuana.  

    “My feeling is that whoever’s producing it, they’re responsible for making sure that it’s safe for their customers,” he said. “But you know someone’s going to cut a corner.”

    Related stories: 

    • Marijuana pill may be better for relieving pain
    • Does pot really lower IQ? It's not so simple
    • Pot may increase stroke risk in younger adults

     

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    Explore related topics: featured, washington, colorado, marijuana, pot, health-and-safety, recreational-marijuana
  • 22
    Apr
    2013
    2:17pm, EDT

    Marijuana pill may be better for relieving pain

    By Rachael Rettner, MyHealthNewsDaily 

     

    A pill form of marijuana may work just as well to relieve pain as the smoked form, but with fewer side effects, new research suggests.

    In the study, people who either smoked marijuana or took the drug dronabinol — a pill that contains the active ingredient of marijuana — were able to hold their hands in a bath of ice water (showing that they could tolerate the pain of the cold temperature) for longer than participants who took a placebo.

    What's more, the pain-reducing effect of dronabinol lasted longer than that of smoking marijuana, the researchers said. While smoking the drug decreased pain sensitivity for about 2.5, the pill continued to have pain-reducing effects for about 4.5 hours. However, analgesic effects of the pill took about an hour to kick in, compared with about 15 minutes for smoking marijuana.

    Medical marijuana is legal in 18 states, and studies have suggested that smoking the drug relieves pain. For instance, a 2010 study found that smoking marijuana eased pain from nerve injuries.

    However, "smoking anything presents certain health risks," said study researcher Ziva Cooper, an assistant professor of clinical neurobiology at Columbia University's Department of Psychiatry. Substances in the smoke can reduce lung function or increase the risk of cancer.

    The new findings suggest a marijuana pill "can produce analgesic effects for longer without the health risks that come along with smoking," Cooper said.

    Study participants were also less likely to say that they found the effects of dronabinol pleasurable, compared with people who smoke marijuana, indicating that the pill has less potential for abuse, Cooper said.

    However, more research is needed to confirm the results. Because the study involved healthy people, it's not clear if individuals who suffer from a condition such as chronic pain would experience the same effect from the pill. (But Cooper noted that, in the past, drugs that worked in early studies to reduce the pain of an ice bath ended were indeed later shown to relieve chronic pain.)

    In addition, the study involved regular marijuana users (who smoked the drug daily), so it's not clear if the results would apply to people who don't regularly consume marijuana. The study was also small, with just 30 people.

    The research provides "additional evidence to suggest that both marijuana and dronabinol can be somewhat effective in reliving pain," said Dr. John Roberts, an oncologist at the Yale School of Medicine who has studied the effects of marijuana's active ingredient on pain, and was not involved in the new study.

    Roberts said there might be a role for each form of the drug in pain relief, depending on the users' preferences. For instance, some people with a pain condition may say that they prefer smoking marijuana because it both reduces their pain and gives them a high. However, the issue of whether to allow patients to use potentially addictive drugs (ones they find pleasurable) is a question for public policy, Roberts said. [ 5 Surprising Facts About Pain ]

    The new study is published today (April 22) in the journal Neuropsychopharmacology.

    More from MyHealthNewsDaily:

    • 10 Medical Myths that Just Won't Go Away
    • 8 Strange Signs You're Having an Allergic Reaction
    • Trippy Tales: The History of 8 Hallucinogens 

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  • 6
    Feb
    2013
    1:38pm, EST

    Pot may increase stroke risk in younger adults

    Rachael Rettner, MyHealthNewsDaily 
    Smoking marijuana may increase the risk of stroke in people under age 55, a new study from Australia suggests. 

    In the study, young stroke patients were about two times more likely to have cannabis detected in their urine compared to patients who were of a similar age, but hadn't had a stroke.

    Although it's an illegal drug, "cannabis is generally perceived as having few serious adverse effects," said study researcher Dr. P. Alan Barber, a professor of clinical neurology at the University of Auckland in New Zealand. The findings suggest this may not be the case, Barber said.

    However, the study only found an association, and not a cause-effect link. Although the researchers took into account each patient's age, gender and race, it's possible other factors might have been responsible for the link. For instance, many of the cannabis users also smoked tobacco, so it was impossible for the researchers to disentangle the effects of tobacco from those of marijuana. Further studies should be conducted to determine if marijuana smoking really can cause stroke, the researchers said.

    Some physicians have reported cases of young patients with no risk factors for stroke experiencing one after heavy marijuana smoking, but few rigorous studies have investigated the link.

    In the new study, Barber and his colleagues analyzed information from 160 patients between ages 18 to 55 who had suffered either an ischemic stroke, which occurs when a blood vessel to the brain is blocked, or a transient ischemic attack, also called a mini-stroke, which is caused by a temporary blockage of a blood vessel. For comparison, the study also included 160 people who visited the hospital for other reasons besides stroke.

    Screening tests of patients' urine showed that 15.6 percent of stroke patients tested positive for marijuana use, compared to 8.1 percent of the other hospital patients. Cannabis users tended to be similar to nonusers in age, cause of stroke and risk factors for stroke and heart disease, such as high blood pressure and high cholesterol.

    Cannabis use has effects on the heart and blood vessels that make a link with stroke possible, Barber said. For instance, cannabis use increases the risk of atherosclerosis, or the buildup of plaque in the arteries, which reduces blood flow and increases the risk of stroke, Barber said.

    The study will be presented this week at the American Stroke Association's International Stroke Conference in Honolulu.

    More from MyHealthNewsDaily:

    • 10 Medical Myths that Just Won't Go Away
    • Myth or Truth? 7 Ancient Health Wisdoms Explained
    • Beyond Vegetables and Exercise: 5 Surprising Ways to Be Heart Healthy  

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  • 14
    Jan
    2013
    3:39pm, EST

    Does pot really lower IQ? It's not so simple

    By Tia Ghose, LiveScience 

    Marijuana permanently lowers IQ by several points in adolescents, according to research published in August. But a new study suggests that factors related to economic class and home life, not marijuana use, may have caused that IQ drop.

    Researchers who conducted the new study, published today (Jan. 14) in the journal Proceedings of the National Academy of Sciences, did not have access to the original data from a cohort of New Zealand teenagers. Instead, Ole Rogeberg, a labor economist at the Frisch Center in Norway, used a computer simulation to show that, in theory, the same IQ effects could be explained by socioeconomic factors that cause IQ-decreasing behaviors.

    The new results are sure to ignite a firestorm of debate over whether marijuana permanently harms the growing brain.

    "The kinds of environments you are in do affect your IQ," Rogeberg said. Good education and challenging jobs can boost intelligence, but "if people are pushed out or decide to move out of these kinds of arenas, they will tend to see an IQ decline, and they will also be the type of people who tend to take up cannabis smoking during adolescence."

    The original study can't rule out the possibility that other factors could play a role in the link between IQ and marijuana usage, said Susan Tapert, a neuropsychologist at the University of California, San Diego, who was not involved in the study, in an email.

    "This was an excellent study – large, and followed the same individuals over time.  Even still, the possibility of some other unmeasured issue to drive this link remains," Tapert wrote.

    The initial study, by researchers Madeline Meier, Terrie Moffitt and Avshalom Caspi of Duke University, relied on an unprecedented amount of data from a cohort of 1,037 people from Dunedin, New Zealand, who have been followed for more than three decades. The exhaustive study tracked people from age 7 onward, subjecting them to IQ tests, collecting blood samples, and interviewing parents and teachers at several points along the way.

    The team found that marijuana lowered IQ by as much as eight points for heavy, lifelong users who started in adolescence. Marijuana use had no effect if people picked up the habit as adults, suggesting that marijuana was especially harmful for developing brains. [ Adolescent Angst: 10 Facts About the Teen Brain ]

    But socioeconomic class and family structure can change IQ over time. For instance, poorer children tend to choose less challenging schools or work, even if they start out with the same IQ as higher-income kids. Economic class may also affect the development of traits like motivation and perseverance that could affect later-life IQ.

    Rogeberg created a mathematical model to see if the apparent effect of marijuana on IQ could be explained by socioeconomic factors.

    He found they could.

    That doesn't mean marijuana is harmless, Rogeberg told LiveScience. Instead, the original researchers should do a more thorough analysis to prove that marijuana, and not other aspects of the pot-smoking lifestyle, cause lower IQ, he said.

    That should include testing to see whether cannabis use altered individual people's IQ trajectories from age 7 onward. Research should also look at the cumulative impact of various factors, such as home life or education level, that may negatively impact IQ, to see if this cumulative effect could explain the drop seemingly caused by pot smoking.

    "It might be the totality of factors could explain a large part of the effect that they found," Rogeberg said.

    In response, the authors of the past scientific paper conducted a new analysis and found that IQ overall remained fairly stable in the Dunedin participants, they said in a statement. They also only included kids from middle-class families, eliminating the effects of socioeconomic status, they said.

    But Rogeberg says those steps can't rule out other factors as the cause for lower IQ.

    "While interesting, the new analysis is not at all sufficient to address these concerns – but I look forward to seeing a fuller analysis in time," Rogeberg said.

    More from LiveScience:

    • Trippy Tales: The History of 8 Hallucinogens
    • 10 Ways to Keep Your Mind Sharp
    • 10 Easy Paths to Self Destruction 

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  • 26
    Dec
    2012
    11:13am, EST

    Link between pot use, mental illness can go both ways in teens

    By Andrew M. Seaman, Reuters

    Marijuana (cannabis) use may be linked to the development of psychotic symptoms in teens -- but the reverse could also be true: psychosis in adolescents may be linked to later pot use, according to a new Dutch study.

    "We have focused mainly on temporal order; is it the chicken or the egg? As the study shows, it is a bidirectional relationship," wrote the study's lead author Merel Griffith-Lendering, a doctoral candidate at Leiden University in The Netherlands, in an email to Reuters Health.

    Previous research established links between marijuana and psychosis, but scientists questioned whether pot use increased the risk of mental illness, or whether people were using pot to ease their psychotic symptoms, such as hallucinations and delusions.

    "What is interesting in this study is that both processes are going on at the same time," said Dr. Gregory Seeger, medical director for addiction services at Rochester General Hospital in upstate New York.

    He told Reuters Health that researchers have been especially concerned about what tetrahydrocannabinol (THC), the active property in pot, could do to a teenager's growing brain.

    "That's a very vulnerable period of time for brain development," and individuals with a family history of schizophrenia and psychosis seem to be more sensitive to the toxic effects of THC, he said.

    A 2010 study of 3,800 Australian teenagers found that those who used marijuana were twice as likely to develop psychosis compared to teens who never smoked pot.

    But that study also found that those who suffered from hallucinations and delusions when they were younger were also more likely to use pot early on. 

    Chicken v. egg 

    For the new study, published in the journal Addiction, the researchers wanted to see which came first: pot or psychosis.

    Griffith-Lendering and her colleagues used information on 2,120 Dutch teenagers, who were surveyed about their pot use when they were about 14, 16 and 19 years old.

    The teens also took psychosis vulnerability tests that asked - among other things - about their ability to concentrate, their feelings of loneliness and whether they see things other people don't.

    Overall, the researchers found 940 teens, or about 44 percent, reported smoking pot, and there was a bidirectional link between pot use and psychosis.

    For example, using pot at 16 years-old was linked to psychotic symptoms three years later, and psychotic symptoms at age 16 were linked to pot use at age 19.

    This was true even when the researchers accounted for mental illness in the kids' families, alcohol use and tobacco use.

    Griffith-Lendering said she could not say how much more likely young pot users were to exhibit psychotic symptoms later on.

    Also, the new study cannot prove one causes the other. Genetics may also explain the link between pot use and psychosis, said Griffith-Lendering.

    "We can say for some people that cannabis comes first and psychosis comes second, but for some people they have some (undiagnosed) psychosis (and) perhaps cannabis makes them feel better," said Dr. Marta Di Forti, of King's College, London, who was not involved with the new research.

    Di Forti, who has studied the link between pot and psychosis, told Reuters Health she considers pot a risk factor for psychosis - not a cause.

    Seeger, who was also not involved with the new study, said that there needs to be more public awareness of the connection.

    "I think the marijuana is not a harmless substance. Especially for teenagers, there should be more of a public health message out there that marijuana has a public health risk," he said.

    Griffith-Lendering agrees.

    "Given the severity and impact of psychotic disorders, prevention programs should take this information into consideration," she said.

    More from NBCNews.com health:

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    Copyright 2013 Thomson Reuters. Click for restrictions.

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  • 5
    Dec
    2012
    12:44pm, EST

    Synthetic marijuana -- aka 'Spice' -- blamed for 11,000 ER visits a year

    MyHealthNewsDaily

    Street drugs known as synthetic marijuana — also known as K2 and Spice — were linked to 11,406 visits to U.S. emergency rooms in 2010, according to a new government report.

    Of these visits, 75 percent involved people between ages 12 and 29, with males accounting for 78 percent of the visits of that age group. In the majority of cases, the patients had used no other substances.

    About 3,800 of the ER visits involved teens between ages 12 and 17, and a recent national survey of high school seniors showed that 11 percent reported using synthetic marijuana in 2011. These findings are "cause for concern," the report from the Substance Abuse and Mental Health Services Administration (SAMHSA) said.

    "Parents, teachers, coaches and other concerned adults can make a huge impact by talking to young people, especially older adolescents and young adults, about the potential risks associated with using synthetic marijuana," SAMHSA administrator Pamela S. Hyde said in a statement.

    There is no age restriction on purchasing the drugs, and their popularity among young people has grown, according to the report.

    The drugs are designed to act on the body in a way similar to marijuana, and have been linked with a number of side effects, including vomiting, rapid heart rate, increased blood pressure, seizures, hallucinations and paranoid behavior.

    "As synthetic cannabinoids have become more available, the number of ER visits involving synthetic cannabinoids has increased," according to the report.

    In July, the Food and Drug Administration Safety and Innovation Act enacted a comprehensive, national ban against the sale of the drugs. But the products are difficult to regulate and may be available online, the report noted.

    The report is based on data gathered from the Drug Abuse Warning Network, a public health surveillance system that monitors drug-related ER visits in the U.S.

    More from MyHealthNewsDaily:  

    • The Old Drug Talk: 7 New Tips for Today's Parents
    • Why Synthetic Marijuana Is More Dangerous Than the Real Thing
    • 3 New Dangerous Drug Habits in Teens

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  • 8
    Nov
    2012
    1:44pm, EST

    New pot laws will be a public health experiment

    By Rachael Rettner, MyHealthNewsDaily 

    The public health impact of legalizing marijuana for recreational use is concerning to some, but there is little evidence to back up these worries, experts say.

    In fact, the passage of new laws in Colorado and Washington essentially amounts to a public health experiment, which researchers can use to gather information on the real harms and benefits of legalizing the drug in the United States, experts said. The laws, passed by voters on Tuesday, allow adults over age 21 to possess or buy up to 1 ounce of marijuana for recreational use.

    "It's an empirical question, and we'll finally have data to assess it," said Rosalie Liccardo Pacula, co-director of the Drug Policy Research Center at the RAND Corporation, a nonprofit research organization. Right now, there are many unknowns because research on the topic is limited, even in countries where the drug is legal.

    Legalizing marijuana clearly has the potential to harm people, Pacula said. The drug temporarily impairs memory, coordination and perception, which affects driving ability and therefore endangers public safety. [See: Effects of Marijuana ]

    Indeed, studies have found that people who drive within a few hours of using marijuana are more than twice as likely to be involved in a car crash compared with other drivers, said Guohua Li, an epidemiologist at Columbia University Mailman School of Public Health, who has researched the effects of marijuana on driving.

    Some studies have linked use of marijuana early in life with an increased risk for mental illness, and one recent study found a link between marijuana use in adolescents and lower IQ later in life.

    But existing studies on the health effects of marijuana have generally been done using a selected population — those who are inclined to use an illegal drug — and not the population as a whole, Pacula said.

    The real effect on public health will depend on how often people use the drug, whether it is used in conjunction with alcohol (which increases impairment), the drug's potency, and the amount of youth use, Pacula said.

    It is reasonable to assume the new laws will lead to an increase in marijuana use by teens, though it's not clear how big this increase will be, Pacula said. Legalization of pot will lead to a drop in the drug's price, and with any drug, lower prices bring increased use, she said. If the drop in price is small, so is the rise in use.

    Another unknown variable is the potency of the drug that becomes available to recreational users. Potency can vary widely, and higher potencies may increase the risk of mental health problems, Pacula said.

    "When we have knowledge of those things, we'll be able to say wither public health is likely to go up or down," Pacula said.

    More from LiveScience:
    • Marijuana: Facts about Cannabis
    • Medical Marijuana: Benefits vs. Risks
    • Hypersex to Hoarding: 7 New Psychological Disorders 

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  • 27
    Aug
    2012
    4:10pm, EDT

    Teen pot use linked to decline in IQ

    David Mcnew / Getty Images

    Teens who smoked marijuana at least four times a week and used marijuana throughout their life saw their IQ drop an average of 8 points, according to a new study.

    By Tia Ghose, LiveScience

    Teens who smoke marijuana see their IQs drop as adults, and deficits persist even after quitting, according to a new study.

    "The findings are consistent with speculation that cannabis use in adolescence, when the brain is undergoing critical development, may have neurotoxic effects," study researcher Madeline Meier of Duke University said in a statement.


    The study followed 1,037 New Zealand children for 25 years. Subjects took IQ tests at age 13, before any of them had smoked marijuana, and again at age 38. Throughout the study, participants also answered several surveys about their drug use.

    Roughly 5 percent of the participants started using marijuana as teenagers. Those who smoked marijuana at least four times a week and used marijuana throughout their life saw their IQ drop an average of 8 points, the equivalent of going from an A to a B student. The drop was not explained by other drug use, years of education, schizophrenia or using marijuana in the day before the test.

    People who eventually quit smoking pot still had lower IQs than they did at the start of the study.

    Interestingly, people who picked up the habit as adults had no IQ drop, suggesting that marijuana may not be as harmful to the mature brain.

    The findings are the first to associate intelligence declines with marijuana use. Past work linked low IQ and marijuana, but couldn't rule out the possibility that people who choose to smoke pot are inherently less smart than abstainers.

    It's not clear why pot is bad for teen brains.

    One possibility is that teenagers are more vulnerable to marijuana's effects on brain chemistry, said Susan Tapert, a neuropsychologist at the University of California, San Diego, who was not involved in the study.

    During adolescence, neural connections are pruned in the hippocampus and the prefrontal cortex, critical regions for learning, memory and planning, Tapert said.

    Those regions may also soak up the active ingredient in marijuana."A lot of the areas that are still developing during adolescent years happen to be the areas with high cannabis receptor density,"  Tapert told LiveScience.

    But those who consistently smoke marijuana may simply make less intellectually stimulating choices at critical points in life.

    "What people tend to do when they're under the influence is different than they would otherwise," Tapert said.

    For instance, pot users may be less inclined to attend classes or do other activities that give the brain a workout. Getting off track early on can also limit future opportunities and thereby reduce IQ, she said.

    Related: 10 Ways to Keep Your Mind Sharp

    "Teens need to view cannabis as not an entirely benign compound, but as something that can impair your judgment and might not be great for your brain," Tapert said.

    The study is detailed Aug. 27 in the journal Proceedings of the National Academy of Sciences.

    Related:  

    • Understanding the 10 Most Destructive Human Behaviors
    • Trippy Tales: The History of 8 Hallucinogens
    • 10 Things You Didn't Know About the Brain

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  • 14
    May
    2012
    12:33pm, EDT

    Pot smoking may help relieve symptoms of MS

    By Rachael Rettner
    MyHealthNewsDaily

    Smoking marijuana may improve some symptoms of multiple sclerosis, a new study suggests.

    Patients with multiple sclerosis in the study had less muscle tightness, also called spasticity, and less pain after they smoked marijuana, compared with after they took a placebo.

    Spasticity is a common symptom of multiple sclerosis (MS) and can cause exaggerated reflexes, spasms and problems walking. Existing medications can ease spasticity, but they cause side effects, and not all MS patients are helped by them.

    However, patients in the study experienced short-term decreases in their abilities to pay attention and concentrate after they smoked marijuana. Patients also reported feeling "high" after smoking marijuana, and two patients withdrew from the study because they felt uncomfortably high.

    More research is needed to confirm the findings and to investigate whether lower doses of marijuana may have similar benefits with fewer adverse effects, said study researcher Dr. Jody Corey-Bloom, professor of neurosciences and director of the Multiple Sclerosis Center at the University of California, San Diego.

    The study is published today (May 14) in the Canadian Medical Association Journal.

    Improved symptoms

    Previous studies have suggested marijuana use may have benefits for MS patients, but most have investigated oral forms of the drug, including mouth sprays and capsules. In addition, most studies have asked patients to report changes in their symptoms, rather than having a researcher objectively assess them.

    In the new study, Corey-Bloom and colleagues evaluated 30 MS patients, 19 of whom were female, and more than half of whom needed walking aids.

    Participants were randomly assigned to receive treatment with a marijuana cigarette or a placebo cigarette, which did not contain delta-9-tetrahydrocannabinol (THC), the active ingredient of marijuana. Participants smoked a marijuana cigarette once a day for three consecutive days under the supervision of a researcher. Eleven days later, participants repeated the procedure, but this time, they switched treatment groups so that everyone received the marijuana cigarette and placebo at some point in the study. On average, participants smoked four puffs of their cigarettes at each session.

    Shortly after each treatment session, the researchers assessed participants with a test specifically designed to measure spasticity.

    After smoking marijuana, participants experienced a 30 percent reduction in spasticity, compared with when they smoked the placebo cigarette, Corey-Bloom said.

    However, patients did not see improvements in the time it took them to walk 25 feet. And 45 minutes after their sessions, participants experienced a small but significant decrease in scores on tests designed to measure attention and concentration.

    Participants were not told whether they recieved a placebo or a true marijuana cigarette, more than half correctly guessed the sessions when they were given marijuana.

    Marijuana prescriptions?

    The researchers are not advocating marijuana prescriptions for MS patients, Corey-Bloom said. They undertook the study to investigate whether anecdotal reports from MS patients about the benefits of marijuana smoking held up under the scrutiny of science. "I'm not a proponent for marijuana smoking at all," Corey-Bloom said.

    Although cannabis may one day be used to treat spasticity in MS patients, delivery through a marijuana cigarette is "probably not the way that it would be done," because of the side effects patients experience, said Dr. Nicholas LaRocca, vice president of health care delivery at the National Multiple Sclerosis Society, who was not involved in the study. "The majority of people with MS experience cognitive changes at some point in their lives," LaRocca said. "We don’t want to add any additional cognitive deficits with treatment," he said.

    Researchers are currently investigating other treatments for spasticity, including exercise and Botox injections. "We need to continue to explore all of those possibilities, because any given person with MS may respond better to one [treatment] than another," LaRocca said.

    Because many studies have not found a benefit of marijuana for MS patients, and because the new study was small, it's important for researchers to replicate the findings, said Dr. Karen Blitz-Shabbir, director of the Multiple Sclerosis Center at North Shore-Long Island Jewish Health System in Manhasset, N.Y.

    Marijuana cigarettes have disadvantages compared with oral forms of the drug, including potential effects on the lungs and problems with administrating a controlled dose, Blitz-Shabbir said.

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  • 31
    Jan
    2012
    1:43pm, EST

    Marijuana mouth spray for cancer patients tough to abuse

    By Rachael Rettner, MyHealthNewsDaily

    The medical marijuana drug Sativex, which could be approved in the United States in the coming years as a treatment for pain relief, has little potential for abuse, experts say.

    The British pharmaceutical company GW Pharmaceuticals is currently testing the drug, which is delivered as a mouth spray and called Sativex, in clinical trials. The company plans to seek U.S. Food and Drug Administration approval for the drug as a treatment for cancer pain when the trials are completed, likely sometime in 2014, a spokesperson for GW Pharmaceuticals told MyHealthNewsDaily.

    The active ingredients in Sativex, known as cannabinoids, are derived from the cannabis plant. It is the first marijuana-based drug to be made by extracting the compounds from the plant, rather than synthesizing them. Two other drugs, Marinol and Cesamet, based on synthetic cannabinoids, were approved by the FDA in the 1980s.

    Because the drug contains THC, the ingredient primarily responsible for marijuana's "high," it's possible people would use the drug for recreational rather than medical purposes.

    "There is no doubt in my mind that there will be people that abuse it," said Dr. Jeffrey Bernstein, director of the Florida Poison Information Center at the University of Miami Miller School of Medicine.

    However, because the drug is delivered through ingestion, rather than smoking, it would take much longer to have an effect — at least an hour, compared with the minutes it takes to get high after smoking marijuana, said Margaret Haney, a professor of clinical neurobiology at Columbia University. This means drug users seeking a high would be less likely to abuse it. "Smoking is a really effective way to get a chemical into the brain," Haney said. The mouth spray "is a far safer administration,"she said.

    And Marinol and Cesamet, which are also administered orally, have a low rate of abuse. "We don’t see a lot of problems from [those]," Bernstein said.

    Not the same high
    GW Pharmaceuticals intends to market Sativex in the United States for treatment of cancer pain. The drug is already approved in United Kingdom, Spain, Canada and New Zealand to treat muscle spasms due to multiple sclerosis, according to the company website.

    Patients can adjust the dose of Sativex to prevent it from entering the blood too rapidly, allowing them to experience symptom relief without the marijuana high, according to GW Pharmaceuticals.

    In addition, while marijuana is a hodgepodge of about 64 different substances, Sativex is composed mainly of two ingredients: THC and another cannabinoid called CBD. The latter component is thought to ameliorate some of the side effects of THC, including the high that marijuana users feel, said Dr. Armando Villarreal, an assistant professor of neurosurgery and pain management at the University of Rochester Medical Center in New York.

    And for habitual marijuana users, the cultural and ritualistic practices that go along with smoking pot, such as passing a joint, may be an important part of the experience, Bernstein said. These rituals cannot be replicated with the spray. "A lot of people that smoke marijuana would rather smoke it," he said.

    Unlikely overdose
    Unlike drugs such as painkillers, which come with a risk of death if people take too much, patients who "overdose" on the marijuana spray would be at little risk for acute health problems, Haney said.

    "What could happen is the person could get very uncomfortably intoxicated," Haney said. But in terms of other serious health effects, "there's none that I know of," Haney said.

    "Marijuana, in the scheme of things, is a relativity safe drug," Bernstein said. "Even as a smokeable drug of abuse, it's relatively safe…compared to cocaine or heroin."

    However, Villarreal noted that for people with psychiatric disorders, smoking marijuana has been shown to make the patients' mental problems worse. It's possible Sativex may also cause this problem in some patients, he said.

    Could it help patients?
    So far, the studies that have been conducted do not provide enough evidence to say Sativex is effective in improving pain symptoms, Villarreal said.

    Sativex has mainly been tested as a drug to treat pain caused by damaged nerves. If the drug is approved by the FDA, Villarreal speculated, its use could be restricted to certain pain patients. Those with cancer pain that is not caused by damaged nerves may not be candidates for the drug, Villarreal said.

    About 1 in 11 people who try pot end up addicted to it, Haney said. It would be interesting to study whether Sativex could help people in dependent marijuana users quit the drug, she said.

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  • 10
    Jan
    2012
    4:35pm, EST

    Smoking pot doesn't hurt lung capacity, study shows

    Smoking a joint a day for up to seven years didn't cause a reduction in lung capacity, a new study shows.

    By Kimberly Hayes Taylor

    Periodically smoking marijuana doesn't appear to hurt lung capacity, the largest study ever conducted on pot smokers has found.

    Even though most marijuana smokers tend to inhale deeply and hold the smoke in for as long as they can before exhaling, the lung capacity didn't deteriorate even among those who smoked a joint a day for seven years or once a week for 20 years, according to the study published Tuesday in JAMA, the journal of the American Medical Association.

    In recent years, studies on marijuana smoking and its effects on lung function have been contradictory. While most studies have shown no effects on the lungs from smoking cannabis, others have shown adverse effects, and still others have shown improvement in lung function. Researchers at the University of California, San Francisco, and University of Alabama at Birmingham knew tobacco smoking causes lung damage and leads to respiratory issues such as chronic obstructive pulmonary disease (COPD), but they wanted to be clear whether smoking marijuana, had similar effects.

    They measured lung function multiple times in more than 5,100 men and women during a 20-year period. In fact, the research shows, some people who regularly smoke marijuana can have a slight improvement in lung function.

    Experts say that people shouldn’t simply take the news as green light to get high, but should also consider other factors.

    “Marijuana is a complicated substance, and for people who are thinking about what they’ve done in the past or are thinking about using marijuana or believing it can help medically, their decision should not be based on lung consideration,” says study co-author Dr. Stefan Kertesz, a researcher and primary care doctor at University of Alabama at Birmingham and the Birmingham VA Medical Center.

    “It’s not a decision about lung health, it’s all the other issues: the risk of addiction, an increase in the chance of having accidents and social functioning.”

    Researchers reached their findings by using data from the Coronary Artery Risk Development in Young Adults, collecting repeated measurements of lung function and smoking from March 1985 to August 2006.  More than half of the participants, or 54 percent, said they were current marijuana smokers, cigarette smokers or both when the study began. The average marijuana use was only a joint or two a few times a month — typical for U.S. marijuana users, Kertesz said.

    The authors calculated the effects of tobacco and marijuana separately, both in people who used only one or the other, and in people who used both. They also considered other factors that could influence lung function, including air pollution in cities studied.

    The analyses showed pot didn't appear to harm lung function, but cigarettes did. Cigarette smokers' test scores worsened steadily during the study.

    Researchers measured how well participants could blow air in and out. A healthy adult can exhale about a gallon of air in one second. Although their study focused on lighter smokers, they found some people who smoked more than a joint a day for seven years, could exhale slightly more air than that.

    Kertesz says that extra strength may come from the habit of deeply inhaling, holding and slowly exhaling marijuana smoke.

    “It’s a tiny increase; it’s not a big increase to lung health,” he says. “So be careful not to say that, ‘Oh, wow! Lungs work better on marijuana.’ That would be totally inaccurate.” 

    Authors say there weren't enough heavy users (those who smoked two or more joints a day) among those in the study to draw firm conclusions on that group.

    Dr. Donald Tashkin, who has studied the relationship between marijuana smoking and lung function for more than 30 years as a professor of medicine at UCLA, says the study confirms what other research has also concluded.

    “This is a well-done study involving more subjects than in the past,” says Tashkin, who is not affiliated with the new study. “The public should take away it’s a confirmatory study, but larger and longer than previous studies demonstrating, once again, that smoking marijuana does not impair lung function, unlike tobacco.”

    Tashkin says scientists have a theory that lung capacity is not affected in marijuana smokers because the chemical THC in marijuana has immunosuppressant properties that interfere with the development of respiratory issues such as COPD. He says this indicates there will be lower rates of COPD, but marijuana smokers are still at risk for chronic bronchitis, which means they tend to have increased cough and mucus. The study didn't look at the risk of lung cancer.

    And Tashkin cautions about drawing overall conclusions from the new work: “We’re only talking about one end point. We’re not looking at lung cancer, chronic bronchitis symptoms. We are not looking at other effects, behavioral effects. We are looking at lung function.”

    The Associated Press contributed to this report.

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  • 29
    Dec
    2011
    2:14pm, EST

    Duh! 11 obvious science findings of 2011

    By Stephanie Pappas, LiveScience

    In science, it's not enough to think something is so. Researchers must show that what  we believe to be true is in fact true, proven through statistically significant and reproducible results. Questioning assumptions is, after all, what science is about.

    Nonetheless, some studies really take the cake in the "duh" department, discovering  things that were already obvious. Here are findings from this year that should come as little surprise.

    1. Unsafe sex is more likely after drinking

    Drinking too much alcohol can impair decision-making. And a study out this year drove this point home: Canadian researchers, reporting results that will be published in January in the journal Addiction, said they ran 12 studies looking at the link between blood alcohol and the likelihood of agreeing to use a condom during sexual intercourse. The more alcohol in a person's system (yes, the drunker they were), the more likely they were to throw caution to the wind and ditch safe sex. Specifically, for every 0.1-milligram-per-milliliter increase in study participants' blood alcohol levels, there was a 5 percent increased likelihood of having unprotected sex.

    2. Men appear confident by suppressing fear, pain and empathy

    When mixed martial arts fighters need to show off masculine strength and confidence, they suppress fear, empathy, pain and shame.

    Yeah, not too shocking: that tamping down those emotions might make someone seem more formidable. But the research, published in December in the journal Social Psychology Quarterly, was aimed at understanding how men manage their emotions and expectations of manhood.

    "Managing emotional manhood, whether it occurs in a locker room or board room, at home or the Oval Office, likely plays a key role in maintaining unequal social arrangements," study author Christian Vaccaro of Indiana University of Pennsylvania said in a statement.

    3. Smoking pot and driving isn't safe

    Who knew, getting behind the wheel while high could be trouble? According to a study published in October in the journal Epidemiologic Reviews, marijuana use increases the risk of car crashes. People who took to the road within three hours of smoking pot, as well as those who tested positive for the drug, were more than twice as likely as other drivers to be involved in a car crash. And that risk increased for those who smoked more frequently and those showing a higher level of the drug in their urine.

    4. Pigs love mud

    Turns out pigs aren't just putting on a show when they haul butt around their muddy quarters, diving into the muck. They actually like it. While mud baths keep pigs cool, a review of research reported in 2011 found wallowing may also be a swine sign of well-being. While the review found the strongest reason noted in the past studies for wallowing was to keep cool, the pigs kept it up through winter months.

    5. Fashion magazines glorify youth

    Surprise, surprise: Fashion mags portray women over 40 sparingly, if at all. Young celebrities and models dominate the pages of these publications, even ones targeted at older age groups. For example, researchers reported in April in the Journal of Aging Studies, that 22 percent of the reader base of Essence is older than 50, but only 9 percent of the women in its pages were even older than 40. Vogue featured only one woman over 40 on its covers in 2010: Halle Berry (then 43).

    6. People with generous partners have happy marriages

    In the realm of unsurprising marriage advice, researchers found this year that generous marriages are happy marriages. Couples with spouses who offer back rubs and other seemingly selfless acts are happier with their relationships than people who report low amounts of generosity in their marriages, according to researchers with the National Marriage Project.

    Half of women and nearly half (46 percent) of men who reported above-average generosity in their marriages described themselves as "very happy" with their relationships. In comparison, only 14 percent of people with low levels of generosity in their marriages said the same.

    7. Parents don't think their kids are doing drugs

    Smoking pot and drinking? Not my daughter! Parents are in denial about their own children's bad habits, according to poll data released in September by the University of Michigan's C.S. Mott Children's Hospital. That study found that while most parents believe at least 60 percent of 10th-graders drink alcohol, only 10 percent thought their own teen did. 

    8. People aren't doing anything in particular on the Internet

    Anyone who has ever gone down an Internet black hole, only to emerge hours (and dozens of Wikipedia articles) later, will be less than shocked at the revelation that online is the place to go for mindless entertainment. According to a Pew Research report released in December, 53 percent of people ages 18 to 29 get online at least once on any given day just to pass the time. Using the Internet to goof off isn't limited just to the young, either: Fifty-eight percent of all adults said they sometimes get on the Internet for no reason other than casual entertainment.

    9. Restricting driver's licenses decreases teen fatalities

    Graduated licenses, which allow teens more freedom behind the wheel as they gain driving experience, save lives. Researchers at the Institute for Research and Evaluation (PIRE) reported in November that fatal automobile crash rates among 16- and 17-year-olds fell 8 percent to 14 percent in states that enacted graduated-licensing laws. Restrictions such as limits on the number of passengers a teen can ferry around and rules against night driving decreased fatal crashes by 13 percent and 9 percent, respectively. Practice (and a little more maturity) makes perfect, it seems.

    10. Most shoppers ignore nutrition labels

    Calories, cholesterol, sugar … yawn. A study published in October found that grocery shoppers pay little attention to the information on nutrition labels. Even shoppers who say they "almost always" read nutrition information aren't likely to take in much information in a real-world shopping environment, the research found. Using an eye-tracking device on study volunteers, researchers found that only about 1 percent looked at information about total fat, trans fat, sugar and serving size on nearly all labels, even though between 20 percent and 31 percent of people said they looked at each of those categories when they shopped. Anything low on the label is particularly unlikely to get attention. The study found that the average consumer doesn't make it past the fifth line.

    11. Presidents outlive their contemporaries

    U.S. presidents tend to live as long or longer than their contemporaries, according to research published Dec. 7 in the Journal of the American Medical Association. Sure, being chief executive is stressful (and eight have died in office, four by assassination), but it turns out the top job in the country comes with perks: great medical care, for example. Presidents also tend to be well-off and well-educated, according to lead researcher S. Jay Olshansky, a professor of public health at the University of Illinois at Chicago. Unsurprisingly, money and knowledge tend to buy health and longevity.

    • Doh! Top Science Journal Retractions of 2011
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