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  • 14
    May
    2013
    12:01pm, EDT

    Report questioning salt guidelines riles heart experts

    By Maggie Fox, Senior Writer, NBC News

    An unusual medical brawl erupted on Tuesday when the influential Institute of Medicine issued a report questioning the basis of years of advice for Americans to cut their salt intake in half.

    The Institute, which advises the federal government on medical issues, concluded that the studies have answered the question poorly.  A panel of experts looked at studies showing the medical effects of eating too much salt, as well as at studies that have been used to suggest that some people may suffer form eating too little salt.

    Its finding: There’s enough evidence to support advising Americans to keep sodium to 2,300 milligrams a day or less, but there’s not enough to support the current, lower target of 1,500 milligrams a day.

    “There is evidence to lower excessive salt intake,” Dr. Brian Strom, a professor of medicine, epidemiology and biostatistics at the University of Pennsylvania, who chaired the panel, told reporters.

    There is also good evidence that lowering intake to around 2,300 milligrams a day decreased the risk of heart disease,” Strom said. But he said that the evidence was absent to support recommendations of taking it as low as 1,500 milligrams a day. And, he said, there were some studies suggesting this could harm some people -- although those studies are also flawed.

    This infuriated the American Heart Association.

    “While the American Heart Association commends the IOM for taking on the challenging topic of sodium consumption, we disagree with key conclusions,” Heart Association CEO Nancy Brown said in a statement.

    “The report is missing a critical component -- a comprehensive review of well-established evidence which links too much sodium to high blood pressure and heart disease.”

    The Institute agrees that Americans eat far too much salt -- more than 3,400 milligrams a day on average. Most is “hidden” salt, in processed foods such as bread and cereal, restaurant meals and especially fast food.

    And studies clearly show that salt raises blood pressure and that cutting salt can lower blood pressure. High blood pressure damages blood vessels and can lead to stroke, kidney failure and heart failure.

    “We knew about all this data and it didn’t change our thinking,” said Dr. Elliott Antman of Brigham and Women’s Hospital and Harvard  Medical School . “We have to take the evidence that we have -- which is strong,” added Antman, a spokesman for the American Heart Association.

    Several studies have suggested that about a quarter of Americans are salt-sensitive -- that their blood pressure is directly and immediately affected by how much salt they eat. But this doesn’t mean that the other 75 percent can pile on the salt with impunity, Antman said.

    “About 90 percent of the population will ultimately develop hypertension as they age,” he said. “Part of this is almost certainly from years of eating too much salt, he added. Eating too much salt can also affect kidney function, he said.

    “An aggressive reduction in sodium is the way to go,” he said.

    Strom would not be drawn into an argument. “What we are saying is the available data is not consistent on outcomes,” he said. “We are not saying that one shouldn’t be lowering excessive salt intake in the general population,” he added.  “There is simply a lack of data showing it is beneficial.”

    And, he said, it is not up to the panel to set a target. “It’s not that we are against (a target intake of) 1,500 milligrams,” he said. “The data are not consistent.”

    The trouble with trying to measure salt intake is that it’s very hard to separate out salt from the rest of the  ingredients in food, said Antman.

    A truly scientifically rigorous study would randomly assign people to eat diffferent amounts of salt daily and watch to see what kind of diseases they develop -- something that would be difficult to set up, police and also difficult to defend, ethically.

    Antman says most Americans get their salt from prepared foods and from restaurants, not from at-home, scratch cooking. What’s needed, he said, is more encouragement for restaurants and food companies to lower sodium content of food.

    The food industry argues that Americans have a taste for salt and they won’t buy products that are salt-free.  Antman agrees that it’s hard.  “We are used to a high sodium content in our food,” he said.

    “But the data say that in just two to three weeks you can train person’s taste buds to become accustomed to a lower sodium content in food.”

    The Center for Science in the Public Interest piled on, too.

    "What the committee failed to emphasize is that most Americans are deep in the red zone, consuming 3,500 to 4,000 milligrams of sodium a day,' the group, which publicizes calorie counts and other food risks, said in a statement.

    "It's clear that those excessive levels increase the risk of high blood pressure, heart attacks, and strokes. Whether we aim for 2,300 or 1,500 milligrams a day is irrelevant until we move down out of the red zone. At restaurants, you can get roughly 2,000 milligrams of sodium from just one burrito, a single-serve pizza, or an order of kung pao chicken, and at least 1,000 milligrams from a typical sandwich or burger."

    The Centers for Disease Control and Prevention has a widget on salt intake here.

     

    Related:

    • Too much salt may trigger autoimmune disease
    • US advises Americans to eat less salt
    • Most teens well down the road to heart disease

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  • 31
    Jan
    2013
    6:01pm, EST

    New stroke guidelines expand use of clot-busting drugs

    By Rachael Rettner, MyHealthNewsDaily
    Some people who've had a stroke can receive a clot-busting drug up to 4.5 hours after their symptoms begin, according to new guidelines from the American Heart Association. 

    Previously, the guidelines said the drug must be delivered within three hours of the onset of symptoms.

    The drug, called tissue plasminogen activator, or tPA, breaks down blood clots in the brain, and can improve stroke symptoms and reduce the risk of disability. It is used only for strokes caused by blood clots, and not those caused by bleeding in the brain. The sooner the treatment is given, the better a patient's chances for recovery, said Dr. Edward Jauch, lead author of the guidelines and director of the Division of Emergency Medicine at the Medical University of South Carolina.

    Currently, just 3 to 5 percent of stroke patients reach the hospital in time to be considered for the treatment, the AHA says. Researchers hope the new guidelines will increase the number of patients who receive the treatment, Jauch said.

    Patients are eligible to receive tPA in the extended time window — 3 to 4.5 hours after stroke symptoms appear — if they are younger than age 80, if their stroke is mild to moderate in severity, if they are not taking anticoagulants (blood thinners), and if they do not have a history of stroke or diabetes, Jauch said.

    Another new recommendation says stroke patients eligible for tPA should receive it within one hour of arriving at the hospital.

    A 2007 European study showed the benefits of using tPA in the extended time window. In 2009, the AHA issued an advisory to doctors about the benefits of using tPA in the extended window, but this is the first time the recommendation has appeared in the organization's official stroke management guidelines. 

    The new guidelines also recommend that hospitals offering specialized stroke treatment should collaborate with facilities that don't have such specialized treatments. For instance, the hospitals might set up a network for "telemedicine," which would allow doctors at special treatment centers to assess a patient remotely via a computer monitor or TV screen. Hospitals also should set up efficient systems that allow stroke patients to be quickly transferred from one hospital to another if needed, Jauch said

    Symptoms of stroke include difficulty speaking (slurred speech) or understanding others, arm weakness or numbness, face numbness or drooping, and blurred vision. If you experience these symptoms, you should call 911 right away, the AHA says.

    More from MyHealthNewsDaily:

    • Beyond Vegetables and Exercise: 5 Surprising Ways to Be Heart Healthy
    • 8 Tips for Healthy Aging
    • 8 Strange Signs You're Having an Allergic Reaction 

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  • 4
    Nov
    2012
    10:42pm, EST

    Ethicist: Study wasted $30m on sketchy therapy for heart patients

    By Art Caplan, Ph.D.

    If you suffer from heart disease, or have had a heart attack and are therefore at risk of dying from another -- what should you do to reduce your risk? An expensive study sought to find an easy fix, but the large trial sponsored by the National Institutes of Health shows that chelation therapy, a controversial alternative medicine therapy that removes heavy metals from the bloodstream, does little good. So what might help these heart patients instead? 

    The old reliable standbys are losing weight, stopping smoking and exercising more. These, of course, are dull and hard to do, and they surely don’t create sexy headlines.

    Metal-removing therapy shows small benefit in heart patients

    Moreover, they don’t make anyone any money in advocating for them. There are many industries that have a powerful stake in your not doing them, and in advertising round the clock to dupe you into yet another day lounging in front of the TV, scarfing down a second triple cheeseburger or guzzling a big gulp sugary soda. Ignore those messages. Losing weight, keeping away from cigarettes and staying fit are the proven ways to reduce risk.

    Chelation, on the other hand, sounds seductively simpler by comparison. A doctor gives you ethylenediaminetetraacetic acid via IV.  This chemical is widely used to dissolve limescale, the chalky deposit found in kettles, hot water boilers and pipes. That is the extent to which the chemical is proven to do any good. There is no scientific reason to explain why something that can dissolve granular, sand-like deposits in your water heater should be capable of clearing out clogged vessels in a heart. 

    Still, the dream of finding a simple fix to a terrible health problem and the agitation by a powerful alternative medicine lobby led the NIH to invest 30 million dollars in a study of chelation. There has never been any evidence that chelation worked to fix heart problems, autism or the many other ailments that its tout. The study results are now out and show a tiny, marginal impact on the health of those who took the treatment. 

    Does that mean that if you have heart disease you should head to the local chelation center? No. Continue to take your same old heart medications. The results of this new trial are so weak, and the issues surrounding how the trial got done so bothersome that it would not be smart to put your aililng heart in the hands of someone giving something that is still very dubious.

    If you suffer from heart disease, it is up to you to take the hard, challenging but proven road: change your lifestyle.  

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  • 4
    Nov
    2012
    10:42pm, EST

    Metal-removing therapy shows small benefit in heart patients

    By Deena Beasley and Bill Berkrot, Reuters

    LOS ANGELES - A controversial therapy to remove heavy metals from the bloodstream was shown in a large trial to cut the risk of another major heart problem in patients who have already suffered a heart attack, but researchers cautioned that the benefit was small and more study is needed.

    Chelation therapy, an alternative treatment dismissed by many medical professionals as quackery, has its origins in unproven 50-year-old theories about the cause of arterial plaques, the fatty deposits that can cause heart attacks.

    Ethicist: Study wasted $30m on sketchy therapy for heart patients

    Despite no clear evidence of a benefit, and the real risk of side effects such as low blood calcium levels, a 2007 survey found that over 100,000 U.S. heart patients had undergone the $5,000 treatment.

    The results, released here at a meeting of the American Heart Association, showed that 26 percent of patients given a series of chelation infusions had a heart attack, stroke, coronary revascularization, were hospitalized for angina, or died, compared with 30 percent of patients treated with a placebo.

    Much of the difference between the two groups was in the need for repeat artery-clearing procedures and patients with diabetes showed the biggest benefit.

    "Our findings are unexpected and additional research will be needed," said Dr. Gervasio Lamas, chief of Columbia University's Division of Cardiology at Mount Sinai Medical Center in Miami Beach, Fla., and the trial's lead investigator. "This does not constitute sufficient evidence to recommend chelation therapy."

    The 1,708-patient trial to assess chelation therapy (TACT) was launched in 2002 under the auspices of the National Heart Lung and Blood Institute and the National Center for Complementary and Alternative Medicine.

    Patients in the study were treated with either a solution containing ethylene diamine tetra-acetic (EDTA), vitamin C, B-vitamins, electrolytes, a local anesthetic and the anti-clotting drug heparin, or a placebo infusion of salt water and a small amount of sugar.

    Dr. Lamas and others said the level of statistical difference between the groups was small and more work needs to be done to rule out whether the results were due to chance.

    "This is a diverse multi-component intervention," said Dr. Paul Armstrong, senior cardiologist at the University Hospital in Edmonton and a professor at the University of Alberta. He cited the absence of a clear biologic rationale for chelation therapy, and described the trial findings as "hypothesis-generating, not practice-changing."

    The size of the trial was scaled down from an initial target of more than 2,300 patients due to enrollment difficulties. In addition, regulators in 2008 temporarily suspended enrollment to clear up issues surrounding patient consent.

    "It is striking that there was difficulty in enrollment despite an increase in the use of this therapy," Armstrong said.

    There was also an unusually high number, 30 percent, of patients who discontinued the therapy during the trial.

    The findings "need to have some confirmation, but nevertheless the trial results are very provocative," said Dr. Mark Hlatky, director of the cardiovascular outcomes research center at Stanford University.

    Chelation treatment has become popular among some parents trying alternative treatments for children with autism, even though the therapy can be dangerous and is based on the unproven idea that such children have heavy metal poisoning.

    "Intriguing as the results are, they are unexpected and should not be interpreted as an indication to adopt chelation therapy into clinical practice," said Dr. Elliott Antman, chairman of the AHA Scientific Sessions Committee and professor of medicine at Harvard Medical School.

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Maggie Fox, Senior Writer, NBC News

Senior health writer for NBCNews.com. With 20 years experience reporting on health, science, medicine and technology, Maggie now specializes in writing health stories that the average reader can understand. Former global health and science editor, Reuters, who established an award-winning and agenda-setting science and health file for the news agency.

Art Caplan, Ph.D.

Art Caplan, Ph.D., is the head of the division of medical ethics at the NYU Langone Medical Center. He's a regular contributor to msnbc.com and the author or editor of 29 books and over 500 journal publications.

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