The study participants were drawn from women already taking HRT. There may be bias introduced by the original choice of taking HRT. Half of the women in the study were then randomly assigned to go off taking HRT

I would guess that, given the studies linking higher breast cancer rates to the use of HRT, the researchers did not/could not ask women not taking HRT to begin.

It is notable that, unlike the Women's Health Inititave study, this study uses progesterone, not progestin, in as the hormone being evaluated.

My husband is 57 and has this insidious disease. It has robbed him of everything he was and enjoyed doing. I am in the process of trying to find a home to put him in.

In his case we believe it was caused by continued and prolonged exposure to lead and manganese as he was a welder of steel for 33 years.

However it comes about - it is something that no one wants to endure. It's like watching an ice cube melt on a hot day, as little by little the person you knew and loved fades away.

I think (hope?) he recognizes me when he sees me, but I'm not sure. I do believe he knows he knows me - but he doesn't know exactly who I am.

Heartbreaking...gut wrenching...life altering...these are a few descriptions that convey the myriad of emotions I go through...every day.

one 25mg injection (by qualified neurologist between C6/C7 in neck to cerebral venous system) of the Natural biological compound Enbrel, Entanercept, our soluble receptor for our immflamatory Cytokine Tumor Necrosis Factor-alpha, Reverses Alzhiemer`s "Disease" in less than 30 minutes in 9 out of 10 diagnosed with such. ( Type this into youtube or National Library of Medicine- PUBMED)

Find a Dr. NOW, That will Rx off label, or Neurosciene Institute (Proffessor Tobinik -Arcoss from UCLA & in Orange county)

or Contact NIH Clinical Trials & "Angel Flight" Can provide free air transport.

Also Life Extention Foundation in Florida is VERY helpful, may still have clinical Tral going on.

Nutrtional sups also target this gene -respounce will take weeks to months but is nessesary to mantain Reversal

Studies do indicate a relationship between uterine cancer and estrogen. Some of the risk is related to normal differences in estrogen levels in women, such as the number of children a woman has - hormone levels change during pregnancy. The same is true of breast cancer. The risks may therefore be different depending on the nature of the hormone replacement therapy. for instance, some HRT regimes just prescribe a standard estrogen dosage for women. Pills like Premarin contain estrogens, but do not mimic the level of estrogens normall found in premenopausal women. Other HRT regimes on blood tests to determine a levels of all three estrogens and then HRT is individualized so that each of the estrogens (there are 3) are in the appropriate balance for a given woman. Whether that level of control decreases risk has not been systematically and widely studied, although there are some results that would support that hypothesis. I would guess that this is the protocol used in this study, although it isn't specified, as the study also uses progesterone, as opposed to the syntethic hormone Progestin. Many studies have shown that Progestin can increase side effectss and risks.

There is a lot to be learned; women have complex endocrine systems and a lot of research needs to be done. I am much more afraid of Alzheimer's than I am of breast cancer, and I had to have a complete hysterectomy when I was in my 40s, so I have no risk of ovarian or uterine cancer.

Thanks for the info KG!

The researchers knew, and the answer is NOT in the post hoc analysis. They STARTED with women who were ALL on HRT. Then half were randomly assigned to go off HRT. So the initial group that was recruited to do the study was women who were all taking HRT. That choice of women taking HRT as a starting point for the research may have introduced bias as those women had some reason to have initially elected to take HRT - especially given the numbers of women that have discontinued HRT after the findings of the Women's Health Initiative that HRT leads to higher incidence of breast cancer. So these women may have had more severe post-menepausal symptoms. The article does not specify, but given it uses progeterone rather than progestin, which is synthetic and the more common drug used in HRT, these women may have been on waht is called bio-identical HRT, whereby the drugs taken are compouded and specific to a woman's own blood/body chemistry. If that is true, most insurance plans cover a very small part of that, and it can be expensive, so these women may also be from a higher socio-economic group. There may also be differences in initial health. This study does not generalize easily to women who were not or have never taken HRT.