Metal-removing therapy shows small benefit in heart patients

By Deena Beasley and Bill Berkrot, Reuters

LOS ANGELES - A controversial therapy to remove heavy metals from the bloodstream was shown in a large trial to cut the risk of another major heart problem in patients who have already suffered a heart attack, but researchers cautioned that the benefit was small and more study is needed.

Chelation therapy, an alternative treatment dismissed by many medical professionals as quackery, has its origins in unproven 50-year-old theories about the cause of arterial plaques, the fatty deposits that can cause heart attacks.

Ethicist: Study wasted $30m on sketchy therapy for heart patients

Despite no clear evidence of a benefit, and the real risk of side effects such as low blood calcium levels, a 2007 survey found that over 100,000 U.S. heart patients had undergone the $5,000 treatment.

The results, released here at a meeting of the American Heart Association, showed that 26 percent of patients given a series of chelation infusions had a heart attack, stroke, coronary revascularization, were hospitalized for angina, or died, compared with 30 percent of patients treated with a placebo.

Much of the difference between the two groups was in the need for repeat artery-clearing procedures and patients with diabetes showed the biggest benefit.

"Our findings are unexpected and additional research will be needed," said Dr. Gervasio Lamas, chief of Columbia University's Division of Cardiology at Mount Sinai Medical Center in Miami Beach, Fla., and the trial's lead investigator. "This does not constitute sufficient evidence to recommend chelation therapy."

The 1,708-patient trial to assess chelation therapy (TACT) was launched in 2002 under the auspices of the National Heart Lung and Blood Institute and the National Center for Complementary and Alternative Medicine.

Patients in the study were treated with either a solution containing ethylene diamine tetra-acetic (EDTA), vitamin C, B-vitamins, electrolytes, a local anesthetic and the anti-clotting drug heparin, or a placebo infusion of salt water and a small amount of sugar.

Dr. Lamas and others said the level of statistical difference between the groups was small and more work needs to be done to rule out whether the results were due to chance.

"This is a diverse multi-component intervention," said Dr. Paul Armstrong, senior cardiologist at the University Hospital in Edmonton and a professor at the University of Alberta. He cited the absence of a clear biologic rationale for chelation therapy, and described the trial findings as "hypothesis-generating, not practice-changing."

The size of the trial was scaled down from an initial target of more than 2,300 patients due to enrollment difficulties. In addition, regulators in 2008 temporarily suspended enrollment to clear up issues surrounding patient consent.

"It is striking that there was difficulty in enrollment despite an increase in the use of this therapy," Armstrong said.

There was also an unusually high number, 30 percent, of patients who discontinued the therapy during the trial.

The findings "need to have some confirmation, but nevertheless the trial results are very provocative," said Dr. Mark Hlatky, director of the cardiovascular outcomes research center at Stanford University.

Chelation treatment has become popular among some parents trying alternative treatments for children with autism, even though the therapy can be dangerous and is based on the unproven idea that such children have heavy metal poisoning.

"Intriguing as the results are, they are unexpected and should not be interpreted as an indication to adopt chelation therapy into clinical practice," said Dr. Elliott Antman, chairman of the AHA Scientific Sessions Committee and professor of medicine at Harvard Medical School.

Discuss this post

Chelation therapy has its uses for removing heavy metals but is extremely dangerous if used in the wrong hands. The article does not mention that children with Autism have died who have been treated with Chelation. It also doesn't mention that the high number of drop outs could have easily proven that the very tiny benefit shown could have been nil.

If you want to reduce cardiac disease and don't want to use modern medicine the CHANGE YOUR DIET and EXERCISE! A good healthy low fat diet with veggies, whole grains, lean meats, etc. is safe and it won't kill you. The problem with our society is that people want to do whatever they want and not have any consequences or take a pill/treatment and "fix it." That is not how life works no matter how much we try to make it so.

  • 6 votes
Reply#1 - Sun Nov 4, 2012 11:15 PM EST

Yes, have you read the China Study or any of the numerous other books on plant-based diets? They have worked for end-stage cardiac patients, people with diabetes, and morbidly obese people. All the diseases that are believed to be caused by the "Western diet", including cancer, at least cancer prevention.

    #1.1 - Mon Nov 5, 2012 6:09 PM EST
    Reply

    Why couldn't the benefit shown be from the heparin, which has an anti-clotting effect and wasn't given to the control group? Or was the amount of heparin too small to have a systemic effect? It seems like the heparin could benefit heart patients the same way aspirin therapy does.

    Moreover, I'm highly suspicious of this study because of the unusually high dropout rate. This study was funded by an alternative medicine organization, and the results could easily be skewed by having some of the high risk individuals or those with impending problems encouraged or incentivized to drop out, therefore inflating the success rate of the chelation group. I would really like to know if the percentage dropping out of the control group was as high as for the experimental group. I suspect not.

    • 3 votes
    Reply#2 - Sun Nov 4, 2012 11:53 PM EST

    I think that it is important to note that this is not the same as using chelation therapy to treat people who have heavy metal poisoning, such as welder who refuse to use respirators.

      Reply#3 - Mon Nov 5, 2012 12:09 AM EST

      EDTA chelation therapy for heart and vascular disease has been utilized by doctors for 60 years. Many studies were published in the past, most of which were positive, but none were large enough to have statistical significance. Still doctors continue to do it because of clinical results in patients. This is the same substance and process of chelation that is used to treat heavy metals, and the effect the treatment has on calcium has been seen as a positive side benefit if you can justify the treatment for metal toxicity. We have published a short history of chelation therapy for heart disease here:

      • 1 vote
      Reply#4 - Mon Nov 5, 2012 1:24 AM EST

      EDTA chelation therapy for heart and vascular disease is an alternative therapy that has been utilized for 60 years. Many smaller studies and papers have been published in the past. We have posted a short history of the treatment here Cardiologists are now faced with a low cost competition to their monopoly on treatment, and there will be considerable backlash.

      • 1 vote
      Reply#5 - Mon Nov 5, 2012 2:03 AM EST

      "Cardiologists are now faced with a low cost competition to their monopoly on treatment, and there will be considerable backlash."
      Claims of medical conspiracies against a treatment regimen throw doubt on its effectiveness. Every magical alternative treatment makes this kind of claim. Medical doctors are always portrayed as greedy evildoers, who suppress simple methods for curing their patients.
      Simple, cheap, aspirin has been found to be helpful in preventing strokes and heart attacks. There was no backlash from cardiologists.
      If EDTA chelation helps heart patients, careful clinical trials will bear it out.

      • 3 votes
      #5.1 - Mon Nov 5, 2012 2:53 AM EST

      There are plenty of obese cardiac patients to go around so cardiologists are not worried. Also if it worked that wonderfully then they'd just add it as an outpatient offering at their office and make even more money. Amazing that every cardiologist I know tells their patients to eat more healthy and exercise to lose the weight, which prevents them from needing their services in the future. They make nothing off of patients who diet and exercise. So much for the monopoly theory.

      • 3 votes
      #5.2 - Mon Nov 5, 2012 9:40 AM EST

      Er, low cost? $5000 smackers for an absolute 4% chance of benefit? For less than that you can pay for a year's worth of vegetables and fish, some walking shoes, and membership at the Y. I would bet that the likelihood of long-term benefit from that "treatment" is much higher.

      • 3 votes
      #5.3 - Mon Nov 5, 2012 10:08 AM EST
      Reply

      Despite warnings from friends and family, my mother in law had chelation therapy as opposed to double bypass. That was 20 years ago, she will be 90 this year. She is in amazing condition, physically and mentally, and she even looks younger than her 3 daughters.

      • 1 vote
      Reply#6 - Mon Nov 5, 2012 8:01 AM EST

      Say/think what you will - my father underwent cheation therapy - his heart ejection rate went from 15 to 45. He died from congestive heart failure 12 years ago, but after two bypass surgeries (6 each time), I have no doubt the chelation therapy improved his quality of life and allowed us to have him with us 4 or 5 extra years.

      • 1 vote
      Reply#7 - Mon Nov 5, 2012 10:07 AM EST

      "Our findings are unexpected" Just how many times do we hear that from some of these experts? Chelation has it's uses ,but like natural chelators and diets ,etc. you need to know what you need to supplement youself with to safely do this. How long do we have to wait for the mainstreme doctors to realize the effect of heavy metals on the body and to do the tests for them?

      • 1 vote
      Reply#8 - Mon Nov 5, 2012 10:52 AM EST

      Chelation therapy was used during WWII for the men that painted the warships. Paint had lead in it back then. One of the benefits besides lead removal is improved ciruclatiion. Metals are in the air, foods, our dental fillings and water. www.acam.org The American College for Advancement in Medicine; www.iaomt.org International Association for Oral Metal Toxicology. Yes, it removes metals and minerals and calcium build up in the arteries is the cause of plaque buildup within the cells of the arteries. The patent ran out on EDTA the initial compound and there was no financial incentive to use it. DMPS, DMSA are also compounds used by certified chelation physicians that are not mainstream. It is extremely beneficial and an alternative to surgery. Yes, diet and exercise help, but not if the toxicity has already manifested. The source of toxicity needs to be removed prior to beginning chelation therapy.

        Reply#9 - Mon Nov 5, 2012 12:56 PM EST

        I can show you the graves of several people that used chelation therapy in home town, 1 being my father. He had 33 treatmments. This stuff kills.

          Reply#10 - Mon Nov 5, 2012 1:35 PM EST

          Chelation itself though over the counter supplements like IP6 taken in the evening before bed can have profound preventative medicine effects on people. As long as you do not interfere with your bodies ability to uptake the minerals that it needs, removing excess is always a good thing. This is especially true when it comes to things such as iron which most Americans get too much of due to food fortified with it... or other heavy metals.

            Reply#11 - Mon Nov 5, 2012 1:36 PM EST

            I have had chelation therapy and found it to be beneficial for me. I was having extreme chest pain before I had chelation therapy and it alleviated the pain about halfway through the treatments. The only downside was that my health insurance would not cover it. I think 5 to 6 thousand for treatment is way less than what it costs for a bypass or angioplasty. If you are having chest pain and the accepted ways of treatment are not helping you, you owe it to yourself to try this non invasive treatment

            • 1 vote
            Reply#12 - Mon Nov 5, 2012 1:42 PM EST

            My father felt great also right upto his massive heart attack. I miss wrote on my earlier post, He actually had 44 treatments the Dr. recommended 33 treatments. When he was first diagnosed his worst blockage was 40% after a couple of years and 44 treatments later his autopsy showed 99% blockage.

              Reply#13 - Mon Nov 5, 2012 1:52 PM EST

              You do know that 99% blockage only means he had a heart attack. You should also know that from the age of 50 the amount of blockage in a persons arteries increases every year. I am not cured, I will have heart disease all of my life and may even die from it, but while I am here I will not discount a viable treatment, a treatment that took every day pain away. It improved my quality of life.

              • 1 vote
              #13.1 - Mon Nov 5, 2012 2:10 PM EST
              Reply

              My father died at 53, for your families sake get real treatment. Bypass is not that bad, I am speaking from experience.

                Reply#14 - Mon Nov 5, 2012 3:47 PM EST

                Did the individuals treating these dying autistics have a lab do a trace mineral analysis to see if they actually had excessive levels of heavy metals in their systems? And were patients supplemented with vital trace minerals such as magnesium while all this chelating was going on? If not, there may be a case for malpractice.

                  Reply#15 - Mon Nov 5, 2012 9:23 PM EST
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