Fungal meningitis deaths climb to 21; 271 infections

CDC

Health officials have found the black mold Exserohilium in unopened vials of injection drugs made by a Massachusetts pharmacy and implicated in an outbreak of fungal meningitis that has killed more than 20 people.

The toll of a growing outbreak of fungal meningitis continued to rise Friday, with 21 deaths and 271 confirmed infections in 16 states linked to contaminated steroid shots from a Massachusetts pharmacy.

There have been 268 cases of fungal meningitis, stroke believed to be caused by fungal meningitis or central nervous system infections tied to the tainted drugs. Three other patients who received shots in their joints, such as hips, knees, shoulders or elbows, have developed infections as well, according to latest figures from the Centers for Disease Control and Prevention.

Nearly 14,000 patients may have received the fungus-contaminated shots distributed by the New England Compounding Pharmacy in Framingham, Mass., since May. All products from the pharmacy have been recalled. 

On Thursday, federal health officials confirmed that they found the fungus Exserohilum rostratum in unopened medication vials of one of three lots of methylprednisolone, a steroid, implicated in the infections and deaths. That discovery confirmed the link between the type of fungus in the drugs and that found in most of the patients who became sick after the shots.

Officials have also confirmed the mold Aspergillus in one infected patient. Another was found to be infected with the fungus Cladosporium. All of the fungi are present in the environment, but rarely cause meningitis.

A second pharmacy connected to the NECC is also being investigated. Ameridose LLC said on Friday that it has agreed to extend a temporary shutdown while state and federal regulators continue an investigation into the company. Ameridose, based in Westborough, Mass., shares some common ownership with NECC. Investigators launched an investigation on Oct. 10.

Most patients got the shots to help relieve back pain. The time it takes for an infection to show up in people who got the tainted shots may be up to four weeks, officials said. 

Patients should be watching for symptoms including fever, headache, stiff neck, nausea and vomiting, sensitivity to light and altered mental status, the Food and Drug Administration said. Symptoms for other infections might include fever, swelling at the injection site, increasing pain, redness, visual changes, discharge from the eye, chest pain or drainage from a surgical site. Anyone who develops these symptoms should seek medical attention. 

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Discuss this post

I have all those symptoms and I never got a shot.

    Reply#1 - Fri Oct 19, 2012 3:07 PM EDT

    see my post below and hope you feel much better soon!

      #1.1 - Fri Oct 19, 2012 3:10 PM EDT

      Guess I shouldn't make light of this case by comparing it to my probable flu mixed with mental tiredness. I've been out of it lately. Its not related to this case obviously, but I just found it odd reading the symptoms.

        #1.2 - Fri Oct 19, 2012 3:12 PM EDT

        And REPUBLICANS want to ABOLISH THE FDA.

        • 1 vote
        #1.3 - Fri Oct 19, 2012 11:05 PM EDT

        This is the SAME FUNGUS that killed people a decade ago due to lax state oversight:

        Five people were sickened and one died in 2002 after receiving epidural injections of the steroid methylprednisolone contaminated with the fungus Exophiala, a new review of public health records shows.

        "It's playing out about the same way, but the order of magnitude is so much greater," said Dr. Jeffrey Engel, an epidemiologist who grappled with the outbreak that started in North Carolina and spread to four other states a decade ago.

        A decade ago, some 870 patients in North Carolina got similar shots, according to press accounts at the time. A 77-year-old woman who was being treated for low back pain developed fungal meningitis and died more than four months after an epidural injection, the Centers for Disease Control and Prevention reported. Four other women ages 52 to 71 were also sickened by the tainted shots, either in their aching backs or in arthritic joints, but they recovered.

        That case is among some 20 incidents since 1990 of recalls, serious illnesses and deaths linked to faulty compounding practices across the U.S., all gleaned from public reports. Some occurred in hospital pharmacies; others happened in compounding pharmacies that aren't required to report adverse events to regulators.

        Engel has been watching the current outbreak closely, dismayed that the problem continues.

        "Haven't we done anything nationally to prevent this?" he said.

        No, Mr. Engel, we haven't. Because the Republicans have ruled the roost during that time, and they believe that federal regulation is evil.

        So more people are dying.

        • 2 votes
        #1.4 - Fri Oct 19, 2012 11:50 PM EDT

        Confusion over the FDA's jurisdiction over compounding pharmacies happened because the Supreme Court threw out part of the oversight legislation in 2003. And the Republican Congress in charge at the time refused to write new authorization for FDA control.

        Sound familiar?

        When senators met nearly a decade ago to consider the dangers of pharmacies that mix or alter drugs with little federal oversight, health officials briefed them on some alarming findings about the safety and efficacy of drugs made by these "compounding pharmacies."

        Dr. Steven Galson, a top official at the Food and Drug Administration, told the Senate Health, Education, Labor and Pensions Committee that in 2001 the agency had done a "limited" survey of drugs from 12 such pharmacies, including hormones, antibiotics, steroids and drugs to treat glaucoma, asthma and erectile dysfunction.

        And he shed some light on the risks from an industry now at the heart of today's unprecedented meningitis outbreak.

        Ten of the 29 drugs failed one or more quality tests, including nine that failed potency testing, some with less than 70 percent of their declared potency. By contrast, in its analyses of more than 3,000 samples from drug manufacturers, who are subject to FDA oversight, only four had quality problems.

        Shortly after Galson testified in 2003, Congress killed an attempt to establish an FDA oversight committee on pharmacy compounding. It was the first in a series of failures to regulate this little-known side of the pharmaceutical industry, which has fought back through Capitol Hill lobbying and political donations.

        Read more: http://www.foxnews.com/health/2012/10/16/how-compounding-pharmacies-rallied-patients-to-fight-regulation/#ixzz29VONkDyl

        Kind of ironic that the GOP is calling for investigations of the FDA over this, when they were the reason it wasn't controlled in the first place.

        • 2 votes
        #1.5 - Sat Oct 20, 2012 12:00 AM EDT
        Reply

        There is the real possibility that these meningitis cases would respond quite well to high dose IV-Vitamin C; intravenously administered; please read Primal Panacea by Dr. Thomas Levy for more information; and YES there is plenty of research and PROOF that vitamin C works against many viral outbreaks

        • 1 vote
        Reply#2 - Fri Oct 19, 2012 3:09 PM EDT
        Comment author avatarSusan Dowsettvia Facebook

        Hello, I just read your comment on the administration of IV-Vitamin C. Along with the research and positive proof of effectiveness of the vitamin C on viral outbreaks, I was wondering if they had run any trials on bacterial contamination such as this horrible spread of induced fungal meningitis? Vitamin C is marvelous!!!

        • 1 vote
        #2.1 - Fri Oct 19, 2012 3:34 PM EDT

        It's FUNGAL. Not viral or bacterial.

        At least read the article before you start dispensing medical advice.

          #2.2 - Sat Oct 20, 2012 12:04 AM EDT

          RealAmericansFirst, thanks for pointing that out!!! It is extremely dangerous for people to make treatment recommendations or post medical advice in the comments section...very dangerous, especially since the majority of these posters are most likely not licensed medical professionals! (I am a pharmacist, and some of the "recommendations" I've seen posted have been downright dangerous and erroneous!)

          • 1 vote
          #2.3 - Sat Oct 20, 2012 4:18 AM EDT
          Reply

          do they know how these became infected?

            Reply#3 - Fri Oct 19, 2012 4:11 PM EDT

            The Government does it.......Population control!!!

              #3.1 - Fri Oct 19, 2012 7:12 PM EDT

              The same way those people 10 years ago became infected. Lack of proper regulatory oversight.

              It's a triumph of "smaller government".

                #3.2 - Sat Oct 20, 2012 12:05 AM EDT
                Reply

                I consider it outrageous this infectious drug is being reported by the media to imply it is a national "EPIDEMIC" when in fact more people died in auto accidents before noon than people dying from this injection (21 people). Just another demonstration of media sensationalism trying to boost their ratings which equals advertising $$$$$$. AKA GREED.

                  Reply#4 - Fri Oct 19, 2012 4:59 PM EDT

                  I for one appreciate the media coverage. It is sure more informative and useful than once more reading about what Romney said about Obama and vice-versa. One of my loved ones has back trouble, too. Not getting methylprednisolone injections, thankfully, but taking oral steriods. If 14,000 people are potentially at risk, to paraphrase our Vice President: "This is a big f***king deal." If this media coverage alerts people who have recently received injections to contact their doctors, it could save lives.

                  • 9 votes
                  #4.1 - Fri Oct 19, 2012 5:11 PM EDT

                  I consider it outrageous this infectious drug is being reported by the media to imply it is a national "EPIDEMIC"

                  Well, it does, technically, meet the defintion of an epidemic.

                  An epidemic is something that affects or tends to affect an atypically large number of individuals within a population, community, or region at the same time.

                  Fungal meningitis is rare. The fungi asociated with this particular outbreak are even more rare when it comes to causing fungal meningitis. It's important to note, epidemic doesn't mean that a disportionatly large number of people die from something (though that often does go along with an epidemic just based o statistics) So, yeah, the number of those infected is atypically high and it's affecting a population, community or region at the same time. Thus, it meets the definition of epidemic.

                  • 4 votes
                  #4.2 - Fri Oct 19, 2012 7:17 PM EDT

                  There's little anyone can do to prevent themselves from being in an auto accident.

                  But there is something you can do to prevent this from happening to you - vote Democratic.

                  • 1 vote
                  #4.3 - Sat Oct 20, 2012 12:06 AM EDT
                  Reply

                  If up to 14,000 were infected, this tragedy has the potential to grow into epic proportions. With the election looming, I hope this story doesn't get crowded out of the headlines. What a nightmare for the families of these victims. For their sakes, I hope the manufacturers were heavily insured.

                  • 3 votes
                  Reply#5 - Fri Oct 19, 2012 4:59 PM EDT

                  Prescription pain medication overdose deaths climb to over 15,000 a year. Now that is really scary. A true epidemic that deserves much more coverage and big-time concern. Where is our government on this one?

                  • 3 votes
                  Reply#6 - Fri Oct 19, 2012 5:05 PM EDT

                  Right know probably one the the millionaire share holders in this company is hanging him or herself or fleeing to some country with no extraditions with all the millions they made. Sad.

                  • 2 votes
                  Reply#7 - Fri Oct 19, 2012 6:12 PM EDT
                  Comment author avatarMichael Aufenkampvia Facebook

                  This is what we get for all the hand sanitizers, livestock anti-biotics, flu shots, and chicken pox vaccinations. Brace yourselves America, there's gonna be a lot more where this came from. I heard today that Whooping Cough has mutated and is making a comeback...

                  • 1 vote
                  Reply#8 - Fri Oct 19, 2012 7:26 PM EDT

                  That best comment I have read in years. Traveling the world and eating real food that would not be allowed here, my stomach turns at the over processed, homogenized, pasteurized pre cooked, and antibiotic pap sold in stores and restaurants. I bet 95% of ameica has no immune system left and cant eat anything. Look at people like The Amish here in america for a sample of how to eat wholesome. Even whole foods sells garbage.

                    #8.1 - Fri Oct 19, 2012 7:52 PM EDT

                    Do you guys not know what live was like prior to antibiotics and sterility. Life expectancy was less than 70 years!! The Amish buy their grain and seeds from farmers in America that use chemicals to get the seeds in the first place. They are not super-immune to the flu. They get it just as quickly as the rest of us. Just not as often because they are not circulating in movie theaters and shopping centers. Which actually will make them less immune in the future since their bodies will not know how to deal with it once they are exposed to strains that we are exposed to and built immunity to.

                    • 1 vote
                    #8.2 - Fri Oct 19, 2012 8:33 PM EDT

                    The whooping cough vaccine was changed because of many complications of receiving the vaccination and so now it's less effective. Therefore many people that were vaccinated in about the last 10-13 years are still at some risk. And then you get people that don't vaccinate on the idea that they're being poisoned. I haven't heard that pertussis has actually mutated. Most bugs do mutate at some point, but I haven't heard of any major change in pertussis. Please confirm your source. I like to stay informed about diseases. They're living organisms after all. As far as vaccines go, we need them. Need I mention Smallpox?

                      #8.3 - Fri Oct 19, 2012 11:50 PM EDT
                      Reply

                      Truly, this is not good. Regardless as to the 'numbers involved'. Anyone who has experienced bacterial, viral or fungal meningitis and is "around to share" their experiences w/ others will attest that fact. The soaring numbers of spinal injections of various steroid compounds, being administered has in part, been a result of clamp-downs by state medical management boards and the DEA & FDA regulatory and enforcement actions on chronic-pain management physicians' both legitimate and non-legit. The efforts in stemming drug (narcotic diversion) have put many chronic pain patients into a newer and vastly more expensive method of attempting to deal w/ their pain. Logically, another example of blow back. This situation is very unfortunate.............for All.

                      • 1 vote
                      Reply#9 - Fri Oct 19, 2012 7:43 PM EDT

                      Difficult to inspect all products put on the market but those who oppose government involvement and promote "small" government should take note. It is clear that total oversight by a manufacture is expensive and there always those who will exchange their hard earned reputations for short term financial gains. It happens too often.

                      • 1 vote
                      Reply#10 - Fri Oct 19, 2012 8:35 PM EDT

                      Just curious - does anyone know how much time has to pass before someone who was injected with the potentially tainted steroids no longer needs to worry about contracting meningitis?

                        Reply#11 - Fri Oct 19, 2012 8:50 PM EDT

                        From what I read on the CDC website, it can take up to 4 weeks before you notice symptoms (which start of kind of mild). If you're two months out from a shot, I think you're probably okay, but it doesn't hurt to err on the side of caution.

                          #11.1 - Fri Oct 19, 2012 11:54 PM EDT
                          Reply

                          I thought the vaccines was design to depopulate global populations by the billions. I guess it's not potent enuff. Maybe the Bilderberg Group will do it again.

                            Reply#12 - Fri Oct 19, 2012 9:22 PM EDT

                            The soaring numbers of spinal injections of various steroid compounds, being administered has in part, been a result of clamp-downs by state medical management boards and the DEA & FDA regulatory and enforcement actions on chronic-pain management physicians' both legitimate and non-legit.

                            Pharma Troll!

                              Reply#13 - Fri Oct 19, 2012 9:59 PM EDT

                              This is disgusting...very disgusting.

                                Reply#14 - Fri Oct 19, 2012 10:30 PM EDT

                                this can happen in a big pharm factory or a locally owned compounding pharmacy as in this case. medicine is not an exact science. that is why it is called the practice of medicine. we all make our own choices. everyday, thousands of healthy pregnant women sit up and bare their backs for the anesthesiologists epidural needle. how many millions of people will roll up their sleeves for the flu shot over the next few months? we bring our babies in good faith to be injected with a cocktail of who knows what. i remember the short lived roto virus vaccine. it was recommended for all babies to prevent a type of diarrhea. many babies died from necrotic ischemic bowel as a direct result of this shot. remember the swine flu shots in ~77 -78? even in this little town we had 3 people on vents for about a month thanks to a contaminate that was a first cousin to giuan barre virus. it paralyzed their diaphragms and they lost the ability to pull a breath. again, we all make the choice for ourselves and our loved ones. optimal whole food nutrition has worked for my family. 3 mostly grown kids, i declined immunizations for them. we brush our teeth often durning the day and have managed to avoid the lidocaine needle at the dentists. every one should be afraid of "shots". its instinctual for kids.

                                .

                                  Reply#15 - Fri Oct 19, 2012 11:40 PM EDT

                                  The FDA is run by who else--Big Pharma. Republican/democrat has nothing to do with it. The FDA wouldn't have caught anything in time. If you think this is a political issue, you're assuredly incorrect. Big pharma is big business and there currently are a number of mass torts due to defective drugs and devices. NSF due to gadolinium, contact lens solution with a fungus that caused blindness for numerous people, Levoquin and its related achilles tendon and other ruptures, etc., etc., etc. This fungal meningitis is one of many situations. The FDA is a farce and hasn't stopped drug makers from making drugs in China where there is no quality control. Add Heparin and Digoxin that were contaminated and killed hundreds and injured thousands more. Wake up sheeple!

                                    Reply#16 - Sat Oct 20, 2012 5:39 PM EDT

                                    My uncle in Houston received steroid shots to treat laryngitis a few months ago and has since been diagnosed with meningitis that is attacking his nervous system. He's still not clear of it and is having terrible troubles... But his shots weren't the infected shots... Right.

                                      Reply#17 - Sat Oct 20, 2012 9:36 PM EDT

                                      Sorry to hear that. Although rare in any case, the meningitis may have come from another source (I think it can be typed by strain). All I can suggest is that you ask lots and lots of questions of the doctors involved. You want the manufacturer's name and lot number of the injection. You want to know what other supplies were used during the procedure (who made the syringe, the needle, the antiseptic lotions or wipes, etc.) If you feel like you are getting nowhere, don't hesitate to call a lawyer. Sometimes you need the power of subpoenas to get access to information that you may not otherwise be able to get. The first step is to get your uncle well. Getting information from the relevant sources can sometimes be difficult, unfortunately. Be persistent. Don't take no for an answer.

                                        #17.1 - Sun Oct 21, 2012 9:32 PM EDT
                                        Reply
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