FDA OKs first new weight-loss pill in 13 years

Belviq, the first weight loss pill approved by the FDA in 13 years, works by activating a receptor in the brain that helps people feel full after eating. Despite concerns about the drug's safety, the FDA and many doctors feel the drug's benefits outweigh the risks. NBC's Robert Bazell reports.

Federal Food and Drug Administration officials approved a new weight-loss pill Wednesday, giving the nod to Belviq used in combination with a reduced-calorie diet and exercise to combat obesity.

The Arena Pharmaceuticals drug, which also goes by the generic name lorcaserin, is one of three new potential weight-loss treatments the agency is considering and the first new weight-loss medication approved in 13 years. More than two-thirds of adult Americans are overweight or obese. 

"Obesity threatens the overall well-being of patients and is a major public health concern," said Dr. Janet Woodcock, the director of the FDA's Center for Drug Evaluation and Research.

Lorcaserin was initially rejected because of concerns about safety issues, particularly concerns about heart valve problems, but a panel this spring agreed that the drug from Arena in conjunction with the Japanese firm Eisai Inc. was now suitable for use. 

The drug works by activating a receptor in the brain that may help a person eat less and feel full after eating smaller amounts of food.

It is approved for use in obese adults with a body mass index or BMI of 30 or greater and in overweight adults with a BMI of 27 or greater if they have at least one weight-related condition such as high blood pressure, type 2 diabetes or high cholesterol. For example, a 5-foot-7 woman who weighed 192 pounds would have a BMI of 30.

The drug was tested in three randomized, placebo-controlled clinical trials involving nearly 8,000 obese and overweight patients, including those with and without type 2 diabetes. They were treated for 52 to 104 weeks. All participants agreed to diet and exercise regimens. Compared with use of a placebo, or sugar pill, patients treated with Belviq for up to one year lost an average of 3 percent to 3.7 percent of their body weight. 

Nearly half of patients without diabetes lost at least 5 percent of their body weight, compared with about a quarter of those who took placebos. In people with diabetes, about 38 percent treated with lorcaserin lost 5 percent of their body weight, compared with about 16 percent treated with placebos. 

The drug is recommended to be discontinued in patients who fail to lose 5 percent of body weight after 12 weeks of treatment because they appear to be unlikely to achieve "clinically meaningful" weight loss. 

Approving lorcaserin will offer big benefits to patients approaching the 30 BMI mark, which increases health risks and decreases the likelihood of future weight loss, said Dr. Jaime Ponce, the new president of the American Society for Metabolic & Bariatric Surgery. 

"I think this is great," he said. "Thirteen years without any other medical option."

Select patients treated in a program that includes diet, exercise and medication may be able to lose weight without resorting to surgery, he added.

Arena Pharmaceuticals will be required to conduct six post-marketing studies including a long-term trial to evaluate cardiovascular risks including heart attacks and stroke. 

Related stories: 

A woman who was desperate for lap band weight-loss surgery had to gain weight to meet qualifications for the procedure that would ultimately help her shed the extra pounds. NBC's Kristen Dahlgren reports.

 

 

 

 

 

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Eat healthier, have some sort of physical activity for at least 45 minutes a day, and again...eat healthier. Calories in equals (3500 to make a pound). I was over weight for years and tried diets, cleanses and fad diets...nothing works or if it does, once you stop...you gain back the weight plus some. Look at the story of the 650 pound virgin David Smith... the guy lost 400lbs just to gain back almost 300lbs in less than two years. You have to have the mentality to make the life choice... there is not a "magic pill" that will get you there.

  • 20 votes
#1 - Wed Jun 27, 2012 2:44 PM EDT

While cutting down on wasting food (by not eating more calories than your body needs) is a great way to attack this problem, a healthy diet isn't measured solely on calories. "Eat healthier" is absolutely right. If someone is eating 4,000 calories a day of pizza and ice cream, simply cutting down to 2,000 calories of pizza and ice cream will only increase their malnutrition.

The problem isn't simply quantity of food, it's choices of food. We can eat carrots and broccoli until our stomachs explode and never get fat. It's only when we graze on sugar and fat all day that we have to worry about how much we're eating.

  • 7 votes
#1.1 - Wed Jun 27, 2012 2:55 PM EDT

wish there was a magic pill!

  • 12 votes
#1.2 - Wed Jun 27, 2012 3:12 PM EDT
Comment author avatarThe Rusty TromboneExpand Comment Comment collapsed by the community

I like to kick fatties as I pass them in the street to encourage them to lose weight. I run up to them, kick them in their fat butts, and run away yelling "you can't catch me fatty fat fat fat! Lose weight fatty!" It's a fool-proof system that works everytime.

  • 8 votes
#1.3 - Wed Jun 27, 2012 3:13 PM EDT

It's not so easy for some people. And if there is a medication that might make it a little easier to eat healthy and excercise isn't that a good thing?

Seriously when I'm trying to lose weight I feel like I'm starving to death. If I could lose it without feeling hunger pains, why wouldn't I want that?

Sometimes people have issues that cause them to gain weight and then they have to take it off.

  • 14 votes
#1.4 - Wed Jun 27, 2012 3:19 PM EDT

They should make those pills pizza or banana pudding flavored.

  • 8 votes
#1.5 - Wed Jun 27, 2012 3:19 PM EDT

@The Rusty Trombone -- I would LOVE for you to kick my fattie as I pass you. I guarantee you would not make it to the end of the block, cause you can't outrun Glock! Show some compassion -- if you have never had a weight problem, be thankful to God.

  • 38 votes
#1.6 - Wed Jun 27, 2012 3:21 PM EDT

Lord have mercy, Rusty, I wouldn't dream of kicking someone's fat butt on the street. The very nerve.

  • 5 votes
#1.7 - Wed Jun 27, 2012 3:30 PM EDT

get some self control. you have convinced yourself that the 'some people have issues losing weight' excuse is fact to make yourself feel better while you sit in the drive thru ordering big macs. eat better, walk instead of watching tv and while you're at it, get your fat kids to stop playing video games.

  • 5 votes
#1.8 - Wed Jun 27, 2012 3:35 PM EDT
Comment author avatarThe Rusty TromboneExpand Comment Comment collapsed by the community

@1ad-1602146 Not if I fly away in my imagination-powered invisible jetpack. Vrroooooooom! Guten Tag Fatty!

  • 4 votes
#1.9 - Wed Jun 27, 2012 3:37 PM EDT

Recently, I lost 13 pounds by drinking WATER and eating healthier. I was in my healthy weight range to start off with, so I imagine someone who is 'obese' would lose more quicker. It's really not difficult, at least for me. I don't work out like I should though. I hate it, but I need to. If you're trying to lose weight, you need to try to tone your muscles- A pound of muscle burns a lot more than a pound of fat at rest! You'll still crave fast food and junk for a while, but that craving WILL go away with time, and your body will start to crave healthy things.

Rusty-

Stop being a jerk. How rude of you to say that.

  • 7 votes
#1.10 - Wed Jun 27, 2012 3:38 PM EDT

Rusty

Does that method work better for you than internet dating? (It seems more personal)

  • 7 votes
#1.11 - Wed Jun 27, 2012 3:48 PM EDT
Comment author avatarJohn-9014Expand Comment Comment collapsed by the community

@1ad-1602146 - Wow! A Fatty and a gun lover. You're a real catch...

  • 4 votes
#1.12 - Wed Jun 27, 2012 3:58 PM EDT

John-

Wtf man. Your mother must be so proud of you. Tell me, did she raise you to put other people down?

Must be a real catch yourself. If my boyfriend ever called anyone a "fatty", I'd drop him so fast.

  • 8 votes
#1.13 - Wed Jun 27, 2012 4:04 PM EDT

Ignore Rusty and others like him who have/will make STUPID comments. They're just PATHETIC TROLLS!!

  • 16 votes
#1.14 - Wed Jun 27, 2012 4:14 PM EDT

Amazing the FDA will approve of another diet pill while contuing to refuse to label GMO foods.

Wnder if the FDA has grown dysfunctional in it's efforts to prolong life through pills pills and more pills!

  • 9 votes
#1.15 - Wed Jun 27, 2012 4:14 PM EDT

So the people who ate SUGAR PILLS didnt lose as much as those who didnt eat them? Duh!!! ;)

  • 4 votes
#1.16 - Wed Jun 27, 2012 4:18 PM EDT

Let us all remember the last weight control pill ok'd by the FDA, it was called speed.

  • 4 votes
#1.17 - Wed Jun 27, 2012 4:34 PM EDT
Comment author avatarThe Rusty TromboneExpand Comment Comment collapsed by the community

@knowsrightandwrong you can't ignore me, I'm in your head, in fact I am you. I am everyone and I am all powerful! CEREAL FOR DINNER!!!!!!

  • 1 vote
#1.18 - Wed Jun 27, 2012 4:37 PM EDT

It is approved for use in obese adults with a body mass index or BMI of 30 or greater*snip* For example, a 5-foot-7 woman who weighed 192 pounds would have a BMI of 30.

*snip* They were treated for 52 to 104 weeks. All participants agreed to diet and exercise regimens. Compared with use of a placebo, or sugar pill, patients treated with Belviq for up to one year lost an average of 3 percent to 3.7 percent of their body weight.

This pill doesn't do anything. If you work out and diet for 1 to 2 years and only lose 3-3.7% and are that woman used for an example, you only lost 5.76 to 7.104 pounds. Someone who weights over 190 would lose 10 pounds in 2 months in water weight alone if they dieted. Just cutting out sodas and going to diet soda and limiting ourselves to 1500 calories a day got my fiancee and myself down 25 pounds each in 6 months. That's without working out at all and we weren't "fat" to begin with. We just want to be to the bottom end of our ideal weight for the wedding. Something isn't right with this study. 3 to 5 pounds a month is what you would be losing if you worked out and watched what you ate normally.

  • 13 votes
#1.19 - Wed Jun 27, 2012 4:37 PM EDT

Have to agree Allen. The amount of weight loss those in the study lost just doesn't make sense, if the people actually did follow through on their eating and exercising.

I have to lose 100pounds, but I wouldn't dream of taking a drug with side effects that may cause me to have heart problems later. I'm losing weight to prevent those types of problems, not cause them! Slow and steady will win the race!

  • 11 votes
#1.20 - Wed Jun 27, 2012 4:45 PM EDT

Sure it's safe. Just like all those other weight loss "magic pills" from past years that had to be pulled, and once they were, you couldn't watch TV for 30 minutes without hearing one of those TV lawyer ads encouraging you to get in on the lawsuits. Mark my words, down the road they will be pulling this one too after serious health problems in people surface.

There is no magic pill to lose weight. The only way to lose 1# is via a 3500 calorie reduction (either by consuming less calories over x# of days, or by a combo of consuming less calories and exercising some off). Some people have an easier/faster time of it. It may suck, but that's the way it is.

  • 7 votes
#1.21 - Wed Jun 27, 2012 4:46 PM EDT

I'm with Allen 968499 The weight loss is miniscule! Avoiding sugar in all forms commercial with an increased exercise program will do better that the drug. The FDA has lost their compass. We don't know the side effects of the weight loss pill. Anybody remember Phen-Fen?

tbran10 @ n2e4u.com

  • 7 votes
#1.22 - Wed Jun 27, 2012 4:48 PM EDT

Allen, You're the first person who made any sense in this conversation. The article itself had me scratching my head. We all have opinions on what causes overwieght or how to treat them (some its not very nice) but I'm with you about the efficacy of this drug.

A 3-4% weight loss over 0ne or two years, why bother? Plus they reduced calories and had an exercise plan? I'd question the data here.

  • 10 votes
#1.23 - Wed Jun 27, 2012 4:50 PM EDT

to mr ltp do you not realize that their are a lot of people on meds that make them gain weight, you do not know if their are emotional issues attached to it. not everybody's life is all the same. until you walk in someones elses shoes keep your mouth shut

  • 4 votes
#1.24 - Wed Jun 27, 2012 5:12 PM EDT

Rusty Thrombone: Your comments are not only crude but ignorant. You should be charged with assault! Obesity is a complex medical disease caused by numerous factors genetics, autoimmune disorders ect. You should count your blessing you obviously have none of these conditions and learn how to be kind to others. Good health is never a guarantee for any of us including YOU! I hope this pill helps some of those in need without too many side effects.

  • 4 votes
#1.25 - Wed Jun 27, 2012 5:15 PM EDT

Sample ad for this drug, "Take the amazing new weight loss pill just approved by the FDA! This pill is proven to do nothing while you diet and exercise in order to lose weight! But, if you take this pill and do not diet or exercise we guaranty you will not lose any weight!

Side effects may include:
Nausea
Loss of vision
Loss of motor control
Loss of limbs (With the added bonus that when you lose a limb, you instantly lose weight!)
Change of eye color to blood red
Visit our website for other fun and exciting side effects you may suffer from!"

/sarcasm

  • 5 votes
#1.26 - Wed Jun 27, 2012 5:17 PM EDT

Doesn't sound like the drug does much. 5% loss is not much. America has been reduced to a society of whiners. No one wants to do the hard work to lose weight. The "secret to losing weight is not easy but very simple=eat less move more. Don't blame McDonalds, Coke, your metabolism, your mom or anything else. If you booty is supersized, you chose to do that.

  • 2 votes
#1.27 - Wed Jun 27, 2012 5:23 PM EDT

Portion control works, did for me, lost 90 lbs in 18 months, 3 years ago and still weigh 195 6'3" sure can't eat as much now.

  • 1 vote
#1.28 - Wed Jun 27, 2012 5:47 PM EDT

I'm so sick of hearing about people and their 'problems' of why they can't lose weight. I've lost and kept off 30lbs over the past year...it's so simple. First of all Donna if people have meds that make them gain weight there are things that person can do to minimize the weight gain that they may cause. Thye have to examine what they eat and why they eat what they do. Switch to a vegetarian diet if that would help...you can have fish and cheese and eggs just cut back on red meat.

If it's emotional problems that are causing weight gain (I mean excessive) then they need to get themselves to a shrink to find out the underlying reasons....no reason not to get help otherwise you will become a shut-in and slowly deteriorate and just get fatter because food is your crutch.

Robin....if people have medical issues then they should seek help...I have no respect for anyone who doesn't respect themselves enough to get help. When 60% of Americans are obese, there are either a lot of fat, laxy ignorant people or America is a country with too many emotionally or genetically stunted people, too ignorant or lazy to seek and find help. I do not believe there are so many physically challenged people due to medication, genetics etc that are obese..If half of that 60% has these so-called conditions that means the other half are just fat and lazy because theyb are fat and lazy and couldn't care less. Well if you're too fat and lazy to car about yourself why should anyone else? Put down the Big Mac....don't drink your 10th Coke of the day and stay away from the donuts. I think a large majority of fat people don't care about being fat and they sure don't care about themselves or their health, I'm fine with that, when they have a heart attack at 30 or can't walk up a flight of stairs or have to pay double on a plane seat I have no sympathy for them. They brought it on themselves and they must reap what they sow...if somwone can't find the time to walk a couple of times around their block a couple of times a week then they desreve whatever they are suffering from whether that be diabetes, kidney failure, hardeing of the arteries, heart disease etc etc.

  • 2 votes
#1.29 - Wed Jun 27, 2012 5:57 PM EDT

@justredd64

Good for you...you knew what the problem was, tackled it and won. 90lbs in 18 months that great, fantastic actually. Your story should inspire people but it's a sad fact people want pity and 'they can't do that'. I say why not, if you can't walk around a block or a few miles a day or walk places instead of driving then they only bring it on themselves. You proved that someone at 280lbs can do it with will-power and eating right and exercise, a lot of people want to blame everything from McDonalds...to pop companies like Coke...they should be looking in the mirror and they will know exactly who to blame for them being fat

But I congratulate you and after 3 years I don't think there's anyway your going back to the bad lifestyle

  • 1 vote
#1.30 - Wed Jun 27, 2012 6:04 PM EDT

Allen-968499 - The pill itself isn't doing anything to cause the body to lose weight. As the article states, it is "activating a receptor in the brain that may help a person eat less and feel full after eating smaller amounts of food". It's only purpose is to help folks keep the amount of calories they eat down.

  • 1 vote
#1.31 - Wed Jun 27, 2012 6:15 PM EDT

ltp - with what you wrote above, I can only imagine the problems you have.

    #1.32 - Wed Jun 27, 2012 7:09 PM EDT

    As far as, "Just putting down the donuts, not drinking so many sodas", recent reports state that sugar is as addictive as nicotine. I personally don't drink soda that is not diet, I prefer water, and just the thought and fear of what a single donut can do to my weight is enough incentive not to indulge. I am right at the borderline for BMI, what my doctor may allow as far as prescribing the new diet pill for me. I flatly refuse to gain weight simply to try it, but I do have issues with my blood pressure, so she may allow me to try it. I have taken a medication for bipolar for years, so clearly, I have cared enough about myself to seek out help, and it does effectively control the mood swings. However, this medication is known to cause weight gain. Obviously, to try, or not to try the new diet drug will be a personal decision.

      #1.33 - Wed Jun 27, 2012 8:18 PM EDT

      Holy @!$%#! The bribes are flying around the FDA as usual.

      Along with USDA these two groups of crooks need oversight committees.

      As bad as it gets in the fed.

      • 1 vote
      #1.34 - Wed Jun 27, 2012 9:20 PM EDT

      Just as a note, as a young person with a congenital valve defect, valve problems such as prolapse and insufficiency (leakage) are actually more common amongst thin people. NOT overweight. I definitely fall into the first category of 'thin', which is perhaps part of the reason why I maintain an 18.5 BMI...

      I'm not sure about stenosis, which is where the valve narrows, as I believe that it can be caused by calcification and plaque...which may be linked to diet. But I'm still pretty certain that it is most common among normal or thin weight individuals.

      Coronary artery disease and certain types of cardiomyopathy on the other hand...

        #1.35 - Wed Jun 27, 2012 10:51 PM EDT

        Obesity is absolutely related to weak minded people that eat too much. The US has the biggest problem out of the entire world because pf PC side of our society. "Oh it's not your falt... It has to be genetics or a changing environment."...lol

        • 3 votes
        #1.36 - Wed Jun 27, 2012 11:36 PM EDT

        Average overweight/obese mindset now: I can keep eating all this junk and just pop this pill!

        I try my hardest not to judge or demean anyone, but in this case, I can't help myself. America is full of obese people who just run to fast food places and substitute it for a meal. They always say, "hey we don't have enough money to cook healthy foods at home." Yet, they always seem to have enough money to buy mounds of soda and fatty foods on a regular (sometimes daily) basis.

        I know in some cases that people have a disease or something else affecting their weight, but after hearing all these miracles and moving stories throughout my 22 years of living, it is definitely possible to conquer this weight problem. No more excuses... if I had a weight problem, no matter what it was from, I would work my butt off to overcome that.

        Yes, you guys are right, I have never had an overweight problem so I don't know what it is like...but you know why? Because I have never let it get that far!

        Sorry if I sound bias and impolite, but at least I'm not sounding like "1ad" and saying that I would pull out my "glock" and shoot a person.

        That's my rant and I'm sticking to it. It pays off to be in shape!

        • 2 votes
        #1.37 - Wed Jun 27, 2012 11:43 PM EDT

        Who cares. All the other weight loss pills are garbge, an FDA stamp of approval means nothing.

        It is infuriating that we pay high insurance rates just so fat asses can take the easy way out and get surgery.

        • 1 vote
        #1.38 - Wed Jun 27, 2012 11:51 PM EDT

        Tea Tarded

        Holy @!$%#! The bribes are flying around the FDA as usual.

        Along with USDA these two groups of crooks need oversight committees.

        As bad as it gets in the fed.

        Aren't they oversight agencies to begin with? When are you moonbats going to get it through your thick skulls that big government is and will always be corrupted? Why give politicans and bureaucrats even more power to sell to the highest bidder? The FDA is only the tip of the iceberg, the federal government is corrupt to the core and it's only getting worse as it grows.

        • 1 vote
        #1.39 - Wed Jun 27, 2012 11:58 PM EDT

        The percentage weight losses they are talking about over one to two years is ridiculously low. If that is all the weight loss people achieved on this medication then it does not appear to do much of anything. Simply switching to a healthy diet and getting even a moderate amount of exercise should lead to greater weight loss than they are talking about. I can not believe that the FDA approved this drug when it showed such minimal results and carries significant risks. If the drug was helping obese people to lose 15% or more of their body weight then it might be worth the risk, but with these absurdly poor results I can not see why they would approve this drug.

        • 1 vote
        #1.40 - Thu Jun 28, 2012 1:34 AM EDT

        If that is all the weight loss people achieved on this medication then it does not appear to do much of anything. Simply switching to a healthy diet and getting even a moderate amount of exercise should lead to greater weight loss than they are talking about.

        But people are already aware of that fact, and most choose not to make the effort. Someone who is unwilling to diet and exercise would find any amount of freebie weight loss to be worth considering.

        It's not as if weight loss drugs are intended for people who are already losing weight the natural way.

          #1.41 - Thu Jun 28, 2012 6:49 AM EDT

          I agree JS (we've been agreeing on a lot lately!). My concern is that people will pop this pill, regardless of the side effects, because they think it's going to help them lose a miraculous amount of weight. Between the side effects and the discouragement, patients on this drug will end up worse than they were when they started taking the drug.

          Whether you are trying to lose 10 pounds or 100 pounds, weight loss is hard work! There will never be a pill that will safely change this fact.

            #1.42 - Thu Jun 28, 2012 9:22 AM EDT

            Moonbat:

            Derogatory term for a liberal activist, implying that s/he is a lunatic. The opposite of wingnut.

            Bwahahaha... Thanx for caring;-)

            I'm sure you don't want to place any blame on Big-Agra/ Pharma, right?

            • 1 vote
            #1.43 - Thu Jun 28, 2012 10:04 AM EDT
            Reply

            Gee, I wonder how much Arena paid the FDA to get this one through the process.

            • 13 votes
            Reply#2 - Wed Jun 27, 2012 2:51 PM EDT

            all drugs cost enormous amounts get thru...near 2 million or better.

              #2.1 - Wed Jun 27, 2012 5:47 PM EDT
              Reply

              i

              • 3 votes
              Reply#3 - Wed Jun 27, 2012 2:54 PM EDT

              You don't need a magic pill for weight loss... I've discovered an even better way and much healthier way to lose weight AND keep it off... Are you ready?? Moderation and regular exercise!!! = )

              • 15 votes
              #4 - Wed Jun 27, 2012 2:55 PM EDT

              Exactly! and you can eat meat if you want to. Eat grass fed. Do NOT buy TYSON, they are known to pump drugs into all factory farming animals. All of them. Organic, free range, grass fed. shop local, in season. Be a regular at the Farmers Market.

              • 13 votes
              #4.1 - Wed Jun 27, 2012 3:02 PM EDT

              AMEN ALL-THAT-IS is just that !

              • 1 vote
              #4.2 - Wed Jun 27, 2012 3:18 PM EDT

              Easier said than done. If it was so simple to eat less and exercise, the diet companies would be out of business. If you have never had a weight problem, be grateful.

              • 4 votes
              #4.3 - Wed Jun 27, 2012 3:23 PM EDT

              1ad-1602146 ~ It is that simple. I lost 80lbs by eating less and getting off my butt. It's called determination, commitment and patience.

              • 4 votes
              #4.4 - Wed Jun 27, 2012 3:28 PM EDT

              Hey you tool, if it were that easy for people who are obese, do you think they would still be fat by choice? I lost 100 pounds in 1998, gained 60 back since then. Lost 20 or so a dozen times in between. I know how to lose weight, and you telling me how it is done is not the issue.

              • 6 votes
              #4.5 - Wed Jun 27, 2012 4:00 PM EDT

              @1ad-1602146 - It IS that simple. You have been brainwashed by diet companies, fast food places, and now pharma. BTW - This new drug talks about losing 3 percent of body weight over 12 months...that's 9 pounds for a 300 pound person! 9 pounds!! Someone is actually going to take medication to lose 3%? That's crazy!!

              • 8 votes
              #4.6 - Wed Jun 27, 2012 4:01 PM EDT

              Buy Tyson's

              As "All-That-Is" points out, it's one stop shopping: you get your meat and your drugs together. You cut out the middle man/drug dealer/doctor.

              • 1 vote
              #4.7 - Wed Jun 27, 2012 4:05 PM EDT

              The consistent perpetration of prepackaged food is what is making our kids fat. Maybe the time has come for the parents to take care of their own kids, while stop making excuses why they can't while letting others take over their role as parent as a manufacturer feeds their kids!

              BTW: Let's move, Afhk, and all other programs continue to fail the fat kids---so why does so much money go into them rather than toward building small but real grocers while helping thier parents learn how to cook, set rules and be good parents????

              • 2 votes
              #4.8 - Wed Jun 27, 2012 4:20 PM EDT

              skunky-shoes ~ I feel bad saying this but I am going to anyways.... Most people are obese because the eat junk all the time and prefer to sit on the couch. They think losing weight is hard because they don't want to put forth the effort and change their lifestyles. I myself have been overweight and used to wish for the magic diet/pill that would let me eat whatever the hell I wanted, while watching my fave shows, all while staying skinny.... Fortunately I finally realized that doesn't exist.

              • 3 votes
              #4.9 - Wed Jun 27, 2012 4:26 PM EDT

              AAAGGGGHHHH. I am not overweight because I AM HUNGRY. I am overweight because I eat when I'm hungry, when I'm sad, when I'm happy, when I'm bored...and the list goes on! When will the world realize this fact?

              It is not: hungry = overweight If that was the case, I'd be as skinny as a board! You all have the ideas, but when you've had a problem for years - it's hard to believe that you can overcome the challenge. I'm extremely successful in all other areas of my life, with the exception of this one area. Maybe I'm afraid? Who knows. I DO know that if people in the world were going to be more supportive when I go to the gym instead of snickering and making rude comments, it would probably be easier to go work out.

              So, I'm make a deal with you. I won't wonder why you are so judgmental and I will pray that you are never in a situation that you need support from outside sources. In return, I would appreciate it if you could give me a high five or a thumbs up when you see me struggling on the treadmill.

              • 7 votes
              #4.10 - Wed Jun 27, 2012 4:37 PM EDT

              Yeah, but if you read the study, it says all of the participants went on a diet and exercised for 1 to 2 years. The pill seems to have slowed down their weight loss since they only lost like 3% of their body weight in 24 months.

              • 1 vote
              #4.11 - Wed Jun 27, 2012 4:41 PM EDT

              Frustrated-2987565 ~ I'm certainly not judging anyone for their weight since I too have struggled my whole life. Even now, when I am sad or angry I would like nothing more than to reach for a heaping bowl of ice cream. However, I have learned to go for a walk or do some push ups instead. I, like you, do not enjoy going to the gym. I too feel uncomfortable. Try working out at home with DVD's or a jump rope. Weight loss is all about losing the excuses and changing your lifestyle.

              • 1 vote
              #4.12 - Wed Jun 27, 2012 4:46 PM EDT

              To all those dealing with weight problems, please try this; Do not bring the danger foods into your house. I have learned not to buy the foods that will tempt me. It saves money too.

              • 5 votes
              #4.13 - Wed Jun 27, 2012 5:30 PM EDT

              cardiologist said lose it or die, no brainer for me...portion control and low fat low sodium lost 90lbs

              • 3 votes
              #4.14 - Wed Jun 27, 2012 5:49 PM EDT
              Reply

              OMG. PILL POPPIN NATION PART DEUX.. go vegetarian. Period. the end. no drugs. nada. stop being fed these crap by the drug companies, you DONT need any drugs to loose weight. Stop eating crap. Walk. Drink Water. lots of water! its not rocket science. you take drugs, then you have to deal with those side effects. Please people. enough with the pills already!!

              • 8 votes
              Reply#5 - Wed Jun 27, 2012 3:00 PM EDT

              There is nothing wrong with eating meat. Being a vegetarian does not automatically lead to weight loss - in fact, a lot of people who go vegetarian end up gaining weight because they make up for a "perceived" lack of food options by eating more carbs.

              Lean meats and egg whites are wonderful for a weight loss diet.

                #5.1 - Thu Jun 28, 2012 9:26 AM EDT
                Reply

                The most common side effects of Belviq in non-diabetic patients are headache,
                dizziness, fatigue, nausea, dry mouth, and constipation, and in diabetic
                patients are low blood sugar (hypoglycemia), headache, back pain, cough, and
                fatigue.

                Sign me up.

                • 8 votes
                Reply#6 - Wed Jun 27, 2012 3:01 PM EDT

                ??????????WTF????????

                • 2 votes
                #6.1 - Wed Jun 27, 2012 3:15 PM EDT
                Reply

                I was in a pizza restaurant the other day and it was truly amazing to watch so many obese people come thru the doors and I'm thinking to myself..... what is wrong with America? Most of the people had to be mininmum of 50 lbs overweight and where are they buying food? at a pizza joint!!!! Americans are just soooo fat its disgusting.

                • 4 votes
                Reply#7 - Wed Jun 27, 2012 3:02 PM EDT

                why were you there?

                • 8 votes
                #7.1 - Wed Jun 27, 2012 3:24 PM EDT

                So only skinny people should enjoy pizza now and then?

                • 10 votes
                #7.2 - Wed Jun 27, 2012 3:26 PM EDT

                If you are heavy you can still have pizza, you just can't get a supreme. Get a plain cheese, hold the extra. It's all about moderation.

                • 7 votes
                #7.3 - Wed Jun 27, 2012 3:31 PM EDT

                Mrsmla4ever-

                You are so right! Moderation, not deprivation...and honestly, they can have any pizza they want to. But don't eat four slices, eat one, and eat a lot of salad at the salad bar. If you try to cut foods like pizza out of your life completely, you set yourself up for failure. Want some cake? Eat a few bites, not a whole slice. You can eat whatever you want, as long as it's in moderation. :)

                Anyone out there trying to lose weight- I use myfitnesspal website. It's a calorie counter. It has almost every food you can buy in their system, you just plug in what you ate and it fills in the calorie content, fat content, protein and everything. It's really helpful. It helped me realize I was drinking about 600 calories a day in the form of sweet tea!

                • 8 votes
                #7.4 - Wed Jun 27, 2012 3:47 PM EDT

                If you try to cut foods like pizza out of your life completely, you set yourself up for failure. Want some cake? Eat a few bites, not a whole slice. You can eat whatever you want, as long as it's in moderation. :)

                I disagree. Food is addictive, treat it like any other addiction. Don't tell an alcoholic to have just one beer, because once he starts, he can't stop. One bite of cake and stop? No way. Complete abstinence is the best way. Sugar is especially addictive, more so than crack.

                Read all about it in a new book Im working on. The working title is called: Stop Stuffing Your Fat Face And Treat Your Addiction, You Disgusting Food Addict: The True Story Of One Man Who Dared To Lose 5 Pounds In Two Weeks.

                • 1 vote
                #7.5 - Wed Jun 27, 2012 4:19 PM EDT

                FOOD IS NOT THE ADDICTION STOOPID----the Act of reaching for food to comfort, to pass the time and for love is what addictive!

                And until the medical dietary and nutritional professionals wake up and realize that all their posturing and preaching means nothing to those in need UNTIL you help them overcome bad habits and addictive behaviors. Only then will they be acceptant to more nutritional choices!

                • 3 votes
                #7.6 - Wed Jun 27, 2012 4:26 PM EDT

                Stoopid:

                I can eat a few bites of cake and stop. Complete abstinence leads people to 'binge', because they haven't had the 'treats' in so long that at some point, they crack. The trick for someone who doesn't have the control to stop after the few bites is drinking water before-hand (fills you up), and eating fruit afterwards. The fruit is sugary, but good for you, and that will still satisfy the sugar/treat craving you have. Telling someone at a birthday party or something similar to NOT eat cake, while they watch everyone else indulge isn't going to work.

                • 4 votes
                #7.7 - Wed Jun 27, 2012 4:28 PM EDT

                Also, on the moderation of favorite foods like pizza, you have to learn to adapt your favorite foods to be healthier. If I want pizza, I don't buy even the frozen ones. I go to the deli, pickup a package of the fresh made, I can read what's on the label whole wheat, high fiber pizza dough, low fat cheese, then load the bugger up with fresh veggies and maybe some low fat meat like chicken. Tasty and kills the pizza craving. I want chicken tenders, I buy fresh chicken, (not the kind injected with the solution stuff), take it home, and bread it myself with flour, spices, milk (lowfat milk), and egg. Pan fry them in just enough oil to make sure they don't stick, eat them with a heaping pile of fresh veggies and yay, there goes that craving. If I want ice creme, I go to the ice creme section and buy ONE small cup of ice creme. It's enough for the craving. I've lost nearly fifty pounds in six months doing this and kicking my own butt at the gym. I suffer from depression so yeah, I fall of my diet and go for potato chips. But I just drag myself back on it, don't buy snack foods other than popcorn, (popped on the stove, no butter), and keep plugging at it. It's hard, yeah, but I feel a lot better. And I still get a cookie now and then! :P

                • 1 vote
                #7.8 - Wed Jun 27, 2012 7:36 PM EDT

                Making things yourself is the best way. I am a crazy do-it-yourselfer and I am still in university full-time. I much prefer the pizza that I make myself with fresh vegetables and homemade low-sodium sauce (carrots and spinach can be delicious on pizza!!!), I can't stomach typical store-bought bread anymore (since when does bread need 25 ingredients? come on, my oatmeal bread recipe has about five...) and if it were my choice, I would yank up all the grass in my backyard and plant a garden full of vegetables, legumes and an apple tree. Oh, and strawberry and raspberry bushes :)

                  #7.9 - Wed Jun 27, 2012 10:55 PM EDT

                  Well, if food in general is designated an addiction, then those affected should never partake of the addiction again. Soo....anyone with a BMI over 25 starting tomorrow may never eat again, according to the logic presented here. Scary. That would overwhelm the morgues, and life insurance, don't you think?

                    #7.10 - Wed Jul 18, 2012 7:28 PM EDT
                    Reply

                    3 to 3.7 percent in a year! Not very good. A few years back I cut way back on my carbs and ate a lot of veggies and lean protien. I lost 1/3 of myself in about six months.

                    This pill requires following a diet and exercise regimin. A good diet and exercise regimin will product results with no pill!

                    • 9 votes
                    Reply#8 - Wed Jun 27, 2012 3:02 PM EDT

                    I completely agree with Laura. 3% - 5% is not all that impressive if these people are taking the pill and followed the nutrition and exercise regimen that they agreed to. By those remarks in the write-up, a 300# person would average a weight loss of 9 pounds over a year at 3%. Either eating healthier or exercising would do that and combined should blow that out of the water. If there was a magic pill, I'd say sign me up but the results they're touting are less than magical or impressive!

                    • 3 votes
                    #8.1 - Wed Jun 27, 2012 3:44 PM EDT

                    I think it is a misprint...They go on to say that if a patient does not have a 5% drop in weight in 12 weeks the drug is not working and should be discontinued. Something doesn't jive...

                    • 2 votes
                    #8.2 - Wed Jun 27, 2012 4:11 PM EDT

                    true skunky-shoes, but the jump from 3% to 5% is only a few more pounds. I know I'm overweight cuz I weight 200 pounds, so if I lost 5% that would be 10 pounds. I've already lost 20 in 3 months, on my own, just by cutting back on calories and being better about exercising.

                    • 3 votes
                    #8.3 - Wed Jun 27, 2012 4:22 PM EDT
                    Reply

                    How about the eat less and exercise part without taking the drugs? WTF is wrong with that?
                    Oh wait...right....lazy fatasses won't do that on their own.

                    • 2 votes
                    Reply#9 - Wed Jun 27, 2012 3:03 PM EDT

                    @dave from philly -- a lot easier said than done. Not all of us "fatasses" are lazy; a lot of us are overweight, but exercise and keep active. Show some compassion. If you have never had a weight issue, be thankful, because it is no fun.

                    • 3 votes
                    #9.1 - Wed Jun 27, 2012 3:25 PM EDT

                    Will all skinny people who do not have any idea of what it is like please STFU?

                    Remember Karma, what you dish out comes back around to bite you in the ass someday. Not that you will start plumping up, but Karma will come back around with another kind of similar challenge for you, with a whole bunch of people in tow who will say how they would never let that happen to them for you to listen to for the rest of your stinking life.

                    • 2 votes
                    #9.2 - Wed Jun 27, 2012 4:14 PM EDT

                    Until they address the genetic challenge only some of us are apparently faced with, the problem will not go away. This is an great way to make a lot of money. People will keep taking this like all the other forms of hope in a bottle, and some group is going to laugh all the way to the bank. The pill to change the genetic switch that we cannot overcome will not be invented EVER. They couldn't make much money one something that would actually work!

                    • 3 votes
                    #9.3 - Wed Jun 27, 2012 4:17 PM EDT

                    It was formally proven that genetics is not the cause-----just a poor excuse.

                    Just because you may be born with a big thick or compacted body frame is not an excuse to get large and fat!

                    • 2 votes
                    #9.4 - Wed Jun 27, 2012 4:29 PM EDT

                    I think some would rather be a "fatass" than an a$$hole. Is there some reason why some of you cannot make your comment without injecting such mean names? This is also what our children are learning from the fine folks such as dave in philly.

                    • 5 votes
                    #9.5 - Wed Jun 27, 2012 4:53 PM EDT

                    Hey sillyshrinks, I love people like you who talk out of their rear end like it is fact...Provide links to the studies and get off your high horse. Speak of your own experiences all you like. but don't reference what you choose to believe as fact to all. The fact is some people have a tremendous challenge that others do not.

                    You may be remembering the study where people were often blaming their thyroid for not being able to control their weight, and it turns out not that many people have thyroid issues.

                    • 1 vote
                    #9.6 - Wed Jun 27, 2012 4:56 PM EDT
                    Reply

                    Yeah well, it wont be long before you see those commercials that start out...."Have you or a loved one taken such and such? Call the offices of Dewey, Rookum and Howe"

                    • 7 votes
                    Reply#10 - Wed Jun 27, 2012 3:03 PM EDT

                    Awesome! a chance to get skinny AND get rich!

                    • 3 votes
                    #10.1 - Wed Jun 27, 2012 3:25 PM EDT

                    Not awesome - maybe they will find some horrible side effects to the heart, etc. Not worth taking.

                      #10.2 - Wed Jun 27, 2012 9:36 PM EDT
                      Reply

                      Well, for some, this pill might just be the jump start they need. I say it is worth a try, for some people. They just might like the better eating and exercise routines!

                      • 3 votes
                      Reply#11 - Wed Jun 27, 2012 3:04 PM EDT

                      If it isn't treated as a "magic" pill, medicine can be used along with exercise can help boost the patient into feeling good enough to keep exercising, and not feeling famished when they reduce their food intake.

                      Some people (including me) have to cut food intake to a pretty drastic minimum to see any weight loss results. Phentermine was prescribed for me, along with a very strict diet and exercise program that I designed but was monitored by my regular family doctor while following to make sure I wasn't doing anything too risky. He agreed that my metabolism was tuned to such a degree that calories required for my body were far below what are conventionally seen as minimum amounts, and that to lose weight I required a lot of exercise every day (no time off).

                        #11.1 - Wed Jul 18, 2012 7:45 PM EDT
                        Reply

                        I do hope that those who choose to try the new weight loss drug does so under their doctors supervision.

                        Especially if it can affect blood surgar. Also one can keep their blood pressure monitored.

                          Reply#12 - Wed Jun 27, 2012 3:08 PM EDT

                          i started at 287lbs 5months ago, i now sit at 250lbs. All i did was start making better choices about what i eat (NOT DIETING), work out 4-6 days a week at least 30-45min. I feel great about everthing, my life is going great. Screw diet pills and diets. You HAVE to change yourself. Slow and steady is how to do it if you want to keep it off.

                          • 9 votes
                          Reply#13 - Wed Jun 27, 2012 3:09 PM EDT

                          Totally agree! I was super skinny until hysterectomy..gained weight like crazy after. Now I have high bp and heart issues. I've been cutting out sodas and sweet tea (hard to do in the south) drinking water, being much more aware of portion control and walking 3 to 4 miles each morning on my elipticle. I've lost 4 pounds in two weeks. May not seem like much, but loosing slowly and correctly will keep it off.

                          • 3 votes
                          #13.1 - Wed Jun 27, 2012 4:01 PM EDT

                          Actually, 4 pounds in 2 weeks is a GREAT steady achievement. Congrats, and keep up the work at getting healthier and feeling better!!! My only suggestion would be to get outside or do some social exercise with someone, it will be easier to stick to :) in the long term.

                            #13.2 - Wed Jun 27, 2012 10:57 PM EDT
                            Reply

                            i dunno about you guys, but i'm going to be filling my "receptors" with more veggies and less pharmaceuticals.

                            • 7 votes
                            Reply#14 - Wed Jun 27, 2012 3:10 PM EDT

                            Laura,

                            Exactly what I was thinking. Walk a 1/2 mile three times a week. Park and walk from the far end of the parking lot, cut down on sugar and carbs, eat lots of tiny veggie and high protein snacks during the day and your evening meal before 6:00 p.m. Guaranteed you will lose at least twice that much (6 pounds) in a year. without that pill (probably expensive too, save that cost and buy better food)

                            Cici

                            • 2 votes
                            Reply#15 - Wed Jun 27, 2012 3:11 PM EDT

                            They lost 3-3.7% of their bodyweight in 1-2 years? A person can lose 1-2% per month with just modest diet and exercise changes. Last year I dropped 12% (25lbs.) of my bodyweight in just 4 months... get off the couch people.

                            • 1 vote
                            Reply#16 - Wed Jun 27, 2012 3:11 PM EDT

                            How fat were they to begin with? Percentage is relative. Also I believe the article was mis-written and it was 3-3.5% MORE than the control group. So if the control lost 10% the drug group lost 13.5%...

                              #16.1 - Wed Jun 27, 2012 3:29 PM EDT

                              Actually a 1% drop in body weight is a reasonable weekly goal. Weight Watchers recommends not exceeding that though, as slower and steady is more successful. People who can lose more are depriving themselves too much to stay the course.

                              • 1 vote
                              #16.2 - Wed Jun 27, 2012 4:20 PM EDT

                              Steve not everyone lives in Boulder CO.

                              Personally I'd say you may have a negative addiction to working out too much!

                                #16.3 - Wed Jun 27, 2012 4:31 PM EDT
                                Reply

                                Humans evolved running down their food to capture it.

                                Now we get in our cars and order a SUPER SIZED order of French Fries in the drive-thru.

                                • 1 vote
                                Reply#17 - Wed Jun 27, 2012 3:12 PM EDT

                                ANOTHER dam pill that in 5-10 years someone will discover that OH @!$%# this stuff will kill you !

                                I AM A NON ATTORNEY SPOKES PERSON , YOU MAY BE ENTITLED TO COMPENSATION ( IF )

                                BUT LEGALIZING A HELPLESS not harming anyone plant that has NEVER killed anyone is a hard choice ???

                                I will never understand ? the fed needs to make Moderation and Exercise the LAW ! To combat the fat ! and if they get over a set # ITS JAIL TIME TILL THEY LOSE IT ! AFTER ALL ( its for their own good ) .

                                • 2 votes
                                Reply#18 - Wed Jun 27, 2012 3:12 PM EDT

                                WHAT??!! The FDA approved it? That must mean that 6 months from now, the drug will be recalled for killing some people and injury countless others.

                                FDA: "Oh, we're sorry, the drug apparently had some "side effects". Oh well."

                                • 5 votes
                                Reply#19 - Wed Jun 27, 2012 3:18 PM EDT

                                When I was in jr high & high school we had health ed (including sex ed) & physical ed. Now with all the cuts in education we are going to be a nation thats FAT & STUPID.

                                • 2 votes
                                Reply#20 - Wed Jun 27, 2012 3:23 PM EDT

                                How bogus ! Most people, even those not over weight, continue to eat after they are full because eating is ENJOYABLE. The only pill that truely works is one that is taped over your mouth with duct tape. Eat sensible, walk some each day. That's enuff to make a difference over time and getting and staying thin is a life long program.

                                  Reply#21 - Wed Jun 27, 2012 3:24 PM EDT

                                  "used in combination with a reduced-calorie diet and exercise to combat obesity" KEY WORDS.

                                  Fast forward 10 years from now where people are filing class action lawsuits claiming this drug caused heart disease and God knows what else. Only in America...unbelievable.

                                  Unless you change your lifestyle, no pill in the world will solve your problems. Throw away the garbage instead of putting it into your body, eat right, and exercise. No prescription required.

                                  • 3 votes
                                  Reply#22 - Wed Jun 27, 2012 3:25 PM EDT

                                  i think the problem with diet pills is people are looking for a miracle cure for obesity. although it does clearly state with low calorie diet and excercise the odds of people actually following those directions are very slim.

                                  • 3 votes
                                  Reply#23 - Wed Jun 27, 2012 3:26 PM EDT

                                  Even with the pills you must DIET and EXERCISE, you can do both of those without the pills. I've done it. I know what I'm talking about. The pills are not magic and you can't take them forever. A person needs to change their behavior. You have to will yourself to stop eating those chips, fries, bacon cheeseburgers or drinking sodas, sweet tea anything else high caloric. We see the ads on TV for "pills and potions" to help people lose weight, the fine print always says "in conjunction with diet and exercise". The article states that if the person isn't doing their part, diet and excercise then that person will no longer get the pills.

                                  When I first moved to NYC in the early 90s I remarked at how thin most of the population seemed back then but now I see more and more people in the subway system taking up two seats I wonder how they can even walk down the subway steps. Then there are the obese ones who take their electric wheel chairs to McDonald's.

                                  Besides there is no drug that is without side effect. Better to steel yourself and lose the weight on your own then to rely on some magic potion.

                                  • 1 vote
                                  Reply#24 - Wed Jun 27, 2012 3:30 PM EDT

                                  hmmm think i'll go surf in the ocean now instead of surfing the net; then i'll have a thick tuna sandwich with lots of sprouts and celery insead of going to Wendy's for lunch...

                                  side affects of surfing in the ocean include but not limited to: pleasantly aching shoulders, water up the nose, red eyes, and the feeling of rocking on a boat while taking a shower...

                                  • 3 votes
                                  Reply#25 - Wed Jun 27, 2012 3:31 PM EDT

                                  ...and possibly being eaten by a hungry shark....

                                  • 2 votes
                                  #25.1 - Wed Jun 27, 2012 3:56 PM EDT
                                  Reply
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