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Daily aspirin might reduce cancer risk

A series of new studies suggest taking a daily dose of aspirin may help prevent, and possibly fight, cancer. Dr. Nancy Snyderman reports.

By Rachael Rettner
MyHealthNewsDaily

Taking aspirin once a day may help prevent cancer, and perhaps even in some cases treat it, a growing body of research suggests.

A new study finds that people who took a low-dose aspirin daily for at least three years were 25 percent less likely to develop cancer than people who didn't take it.

Aspirin also reduced the risk of death from cancer by nearly 40 percent after five years, the researchers said.

The reduced risk of death may be due in part to a decrease in cancer's ability to spread to other organs. In a second study, researchers found a daily dose of aspirin led to a 36 percent reduction in the risk of being diagnosed with cancer that spread to other organs.

This suggests aspirin is likely "to be an effective additional treatment after the diagnosis of cancer," Dr. Peter Rothwell, one of the study's researchers and a neurologist at the University of Oxford in England, told MyHealthNewsDaily.

Taking a daily aspirin has been found to have a variety of health benefits, said Dr. Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital in N.Y., including a reduced risk of heart attack and stroke.

However, more research is needed before aspirin can be recommended to reduce the risk of cancer. That's because the new study analyzed data from previous studies that were not designed to test the effect of aspirin on cancer prevention. "A study has to be specifically designed to prove a point," said Bernik, who was not involved in either new study.

People should speak with their doctors before deciding to take a daily aspirin, Bernik said.

Cancer prevention

Previous studies have found aspirin reduces the risk of death from cancer over the long term. However, the effect of aspirin on cancer in the short term, as well as its effect on developing cancer in the first place, was less clear.

Rothwell and colleagues analyzed data from 51 studies involving more than 77,000 people, in which about half of participants were randomly assigned to take a daily dose of aspirin.

There were fewer deaths among the people assigned to take a daily aspirin, compared with people who did not take aspirin (562 deaths versus 664 deaths).

In an analysis of six of the studies in which people took low doses of aspirin, there were three fewer cases of cancer yearly per 1,000 people in the aspirin group, compared with the group that did not take aspirin, but this effect did not show up until participants had taken aspirin for three years.

Side effects

Aspirin has side effects, including an increased risk of gastrointestinal bleeding. However, the researchers found that after about three years, the increased risk of major bleeding went away, as did aspirin's heart benefits. What was left was the reduced risk of cancer.

"For most individuals, the risk-benefit calculus of aspirin seems to favor aspirin’s long-term anti-cancer benefit," Drs. Andrew Chan and Nancy Cook, both of Brigham and Women’s Hospital in Boston, wrote in an editorial accompanying the study.

Because the findings are new, it will take time for researchers to decide whether guidelines should be changed to include a recommendation of aspirin for cancer prevention, said Eric Jacobs, strategic director of pharmacoepidemiology at the American Cancer Society. Such guidelines would have to take into account who is most likely to benefit from the recommendation, Jacobs said.

The study and editorial will be published tomorrow (March 21) in the journal the Lancet. The study had no funding and no input from drug companies, but the lead researcher has has been paid by several pharmaceutical companies for his work with them.

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